Natural course of mild Graves' orbitopathy: is it a chronic remitting or a transient disease?

被引:15
作者
Anagnostis, P. [1 ]
Boboridis, K. [2 ]
Adamidou, F. [1 ]
Kita, M. [1 ]
机构
[1] Hippokrat Hosp Thessaloniki, Dept Endocrinol & Diabet, Sarantaporou 10, Thessaloniki 54640, Greece
[2] Aristotle Univ Thessaloniki, Univ Dept Ophthalmol 1, Thessaloniki, Greece
来源
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION | 2017年 / 40卷 / 03期
关键词
Graves' disease; Graves' orbitopathy; Natural course; TERM-FOLLOW-UP; OPHTHALMOPATHY; HISTORY; HYPERTHYROIDISM; EXOPHTHALMOS; PREVALENCE; MANAGEMENT;
D O I
10.1007/s40618-016-0555-0
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background/ Aims The natural course of Graves' orbitopathy ( GO) has been poorly documented. The aim of this review is to provide current knowledge regarding the natural course of mild GO, trying to address the issue of whether and to what extent it constitutes a chronic remitting or transient disease. Methods We systematically searched PubMed for English language publications until August 2016 under the following terms: " Graves' orbitopathy" OR " Graves' ophthalmopathy" OR " thyroid eye disease" AND " natural course" OR " natural history". Results Few studies have investigated the course of mild orbital disease in patients with GO. Large controlled trials are lacking and data can be extracted mainly from small retrospective and some prospective studies, after excluding patients who had received radioiodine for thyrotoxicosis or surgical treatment for GO. In general, more than half of GO patients may show spontaneous improvement in their clinical features, whereas no safe conclusions can be drawn with regard to complete resolution, with percentages ranging from 6 to 58 %. Conclusions The question whether mild GO is a remitting, albeit chronic disease, or even a transient event in the course of Graves' disease, remains currently unanswered.
引用
收藏
页码:257 / 261
页数:5
相关论文
共 19 条
[11]   NATURAL-HISTORY OF THYROID-ASSOCIATED OPHTHALMOPATHY [J].
PERROS, P ;
CROMBIE, AL ;
KENDALLTAYLOR, P .
CLINICAL ENDOCRINOLOGY, 1995, 42 (01) :45-50
[12]  
RUNDLE FF, 1957, METABOLISM, V6, P36
[13]   Late reactivation of thyroid orbitopathy [J].
Selva, D ;
Chen, C ;
King, G .
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 2004, 32 (01) :46-50
[14]   PREVALENCE, NATURAL-HISTORY AND SURGICAL-TREATMENT OF EXOPHTHALMOS [J].
STREETEN, DHP ;
ANDERSON, GH ;
REED, GF ;
WOO, P .
CLINICAL ENDOCRINOLOGY, 1987, 27 (01) :125-133
[15]   OCCURRENCE OF OPHTHALMOPATHY AFTER TREATMENT FOR GRAVES HYPERTHYROIDISM [J].
TALLSTEDT, L ;
LUNDELL, G ;
TORRING, O ;
WALLIN, G ;
LJUNGGREN, JG ;
BLOMGREN, H ;
TAUBE, A .
NEW ENGLAND JOURNAL OF MEDICINE, 1992, 326 (26) :1733-1738
[16]   Prevalence and Natural History of Graves' Orbitopathy in a Large Series of Patients With Newly Diagnosed Graves' Hyperthyroidism Seen at a Single Center [J].
Tanda, M. L. ;
Piantanida, E. ;
Liparulo, L. ;
Veronesi, G. ;
Lai, A. ;
Sassi, L. ;
Pariani, N. ;
Gallo, D. ;
Azzolini, C. ;
Ferrario, M. ;
Bartalena, L. .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2013, 98 (04) :1443-1449
[17]   OPHTHALMIC GRAVES-DISEASE - NATURAL-HISTORY AND DETAILED THYROID-FUNCTION STUDIES [J].
TENG, CS ;
YEO, PPB .
BRITISH MEDICAL JOURNAL, 1977, 1 (6056) :273-275
[18]   Long-term effects of Graves' ophthalmopathy on health-related quality of life [J].
Terwee, C ;
Wakelkamp, I ;
Tan, S ;
Dekker, F ;
Prummel, MF ;
Wiersinga, W .
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2002, 146 (06) :751-757
[19]   CLASSIFICATION OF EYE CHANGES OF GRAVES DISEASE [J].
WERNER, SC .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1969, 29 (07) :982-+