Angiotensin-converting enzyme gene polymorphism and digestive system cancer risk: A meta-analysis based on 9656 subjects

被引：5

作者：

Abdeahad, Hossein ^{[1
]}

Avan, Amir ^{[2
,3
]}

Khazaei, Majid ^{[2
,4
]}

Soleimanpour, Saman ^{[5
]}

Ferns, Gordon A. ^{[6
]}

Fiuji, Hamid ^{[7
]}

Ryzhikov, Mikhail ^{[8
]}

Bahrami, Afsane ^{[9
]}

Hassanian, Seyed Mahdi ^{[1
,2
]}

机构：

[1] Mashhad Univ Med Sci, Dept Clin Biochem, Fac Med, Mashhad, Razavi Khorasan, Iran

[2] Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Mashhad, Razavi Khorasan, Iran

[3] Mashhad Univ Med Sci, Dept Modern Sci & Technol, Fac Med, Mashhad, Razavi Khorasan, Iran

[4] Mashhad Univ Med Sci, Dept Med Physiol, Fac Med, Mashhad, Razavi Khorasan, Iran

[5] Mashhad Univ Med Sci, Sch Med, Dept Microbiol & Virol, Mashhad, Razavi Khorasan, Iran

[6] Brighton & Sussex Med Sch, Div Med Educ, Brighton, Sussex, England

[7] Payame Noor Univ, Dept Biochem, Mashhad, Razavi Khorasan, Iran

[8] Washington Univ, Sch Med, Div Pulm & Crit Care Med, St Louis, MO USA

[9] Birjand Univ Med Sci, Cellular & Mol Res Ctr, Birjand, Iran

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 2019年 / 120卷 / 12期

关键词：

angiotensin-converting enzyme; colorectal cancer; gastric cancer; Renin-angiotensin system; II TYPE-1 RECEPTOR; INSERTION/DELETION POLYMORPHISM; BREAST-CANCER; HEPATOCELLULAR-CARCINOMA; COLORECTAL-CANCER; I/D POLYMORPHISM; ASSOCIATION; INHIBITORS; SURVIVAL; BLOCKERS;

D O I：

10.1002/jcb.28955

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The angiotensin-converting enzyme (ACE) is the major regulator of the renin-angiotensin system, and it has been reported that genetic polymorphisms at this locus are associated with risk in numerous types of human cancers. In the current meta-analysis, we aimed to evaluate the association between the ACE Gene insertion/deletion (I/D) polymorphism (DD vs II) and digestive system cancer susceptibility. A total of 19 case-control studies among 3722 patients with seven different types of cancer were included in this meta-analysis. In the pooled analysis, the relationship between the ACE I/D polymorphism and digestive system cancer risk was not statistically significant (odds ratio [OR], 0.93; 95% confidence interval [CI], 0.68-1.29; P = 0.65; random model). Furthermore, subgroup analyses by cancer type also did not reveal an association between ACE polymorphisms and colorectal cancer (OR, 1.14; 95% CI, 0.823-1.58; P = 0.43; random effect model) and gastric cancer (OR, 0.79; 95% CI, 0.51-1.22; P = 0.28; random effect model). These findings indicate that ACE polymorphisms in the digestive tract may still affect the survival of cancer patients, and future studies into the topic of effect of ACE on cancer prognosis are warranted.

引用

页码：19388 / 19395

页数：8

共 33 条

[1] Association between the angiotensin-converting enzyme (insertion/deletion) and angiotensin II type 1 receptor (A1166C) polymorphisms and breast cancer among Brazilian women [J].