Fulminant hepatic failure (FHF) is a condition with a sudden onset of necrosis followed by degeneration of hepatocytes, without any previously established liver disease, generally occurring within hours or days. FHF is associated with a wide spectrum of neuropsychiatric alterations ranging from stupor to coma, culminating in death. in the present study FHF was induced in rats by the administration of thioacetamide (TAA). Oxidative stress is thought to play a prominent role in the pathophysiology of cerebral changes during FHF leading to the assumption that antioxidants might offer protection. Hence, in the present study the protective effect of C-Phycocyanin (C-PC), a natural antioxidant, was evaluated on TAA-induced tissue damage. C-Phycocyanin was administered intraperitoneally twice at 24 h interval (50 mg/kg body weight) along with the hepatotoxin TAA (300 mg/kg body weight). The animals were sacrificed 18 h after the second injection of TAA treatment and various biochemical parameters were analysed in liver, serum and brain tissues. These studies revealed significant prevention of TAA-induced liver damage by C-PC, as evidenced by a) increase in survival rate; b) the prevention of leakage of liver enzymes (AAT and AST) and ammonia into serum; c) increase in prothrombin time and d) liver histopathology. Ultrastructural studies of astrocytes of different regions of brain clearly showed a decrease in edema after C-PC treatment. TAA-induced histopathological lesions in different regions of the brain namely cerebral cortex, cerebellum and pons medulla were significantly reduced by the co-administration of C-PC with TAA. Further C-PC treatment resulted in a) decrease in the levels of tryptophan and markets of lipid peroxidation and b) elevation in the activity levels of catalase, glutathione peroxidase in different regions of brain. These studies reveal the potential of C-PC in ameliorating TAA-induced hepatic encephalopathy by improving antioxidant defenses. (c) 2006 Elsevier B.V. All rights reserved.
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Taipei Vet Gen Hosp, Div Gastroenterol, Dept Med, Taipei, Taiwan
Natl Yang Ming Univ, Sch Med, Taipei 112, TaiwanTaipei Vet Gen Hosp, Div Gastroenterol, Dept Med, Taipei, Taiwan
Chu, Chi-Jen
Hsiao, Ching-Chin
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Taipei Vet Gen Hosp, Div Gastroenterol, Dept Med, Taipei, Taiwan
Natl Yang Ming Univ, Sch Med, Taipei 112, TaiwanTaipei Vet Gen Hosp, Div Gastroenterol, Dept Med, Taipei, Taiwan
Hsiao, Ching-Chin
Wang, Teh-Fang
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Armed Forces Sungshan Hosp, Taipei, TaiwanTaipei Vet Gen Hosp, Div Gastroenterol, Dept Med, Taipei, Taiwan
Wang, Teh-Fang
Chan, Cho-Yu
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Taipei Vet Gen Hosp, Dept Med Res & Educ, Taipei, Taiwan
Natl Yang Ming Univ, Sch Med, Taipei 112, TaiwanTaipei Vet Gen Hosp, Div Gastroenterol, Dept Med, Taipei, Taiwan
Chan, Cho-Yu
Lee, Fa-Yauh
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Taipei Vet Gen Hosp, Div Gastroenterol, Dept Med, Taipei, Taiwan
Taipei Vet Gen Hosp, Div Gen Med, Dept Med, Taipei, Taiwan
Natl Yang Ming Univ, Sch Med, Taipei 112, TaiwanTaipei Vet Gen Hosp, Div Gastroenterol, Dept Med, Taipei, Taiwan
Lee, Fa-Yauh
Chang, Full-Young
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Taipei Vet Gen Hosp, Div Gastroenterol, Dept Med, Taipei, Taiwan
Natl Yang Ming Univ, Sch Med, Taipei 112, TaiwanTaipei Vet Gen Hosp, Div Gastroenterol, Dept Med, Taipei, Taiwan
Chang, Full-Young
Chen, Yi-Chou
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Taipei Vet Gen Hosp, Div Gastroenterol, Dept Med, Taipei, TaiwanTaipei Vet Gen Hosp, Div Gastroenterol, Dept Med, Taipei, Taiwan
Chen, Yi-Chou
Huang, Hui-Chun
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Taipei Vet Gen Hosp, Div Gastroenterol, Dept Med, Taipei, Taiwan
Natl Yang Ming Univ, Sch Med, Taipei 112, TaiwanTaipei Vet Gen Hosp, Div Gastroenterol, Dept Med, Taipei, Taiwan
Huang, Hui-Chun
Wang, Sun-Sang
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Taipei Municipal Gan Dau Hosp, Taipei, Taiwan
Natl Yang Ming Univ, Sch Med, Taipei 112, TaiwanTaipei Vet Gen Hosp, Div Gastroenterol, Dept Med, Taipei, Taiwan
Wang, Sun-Sang
Lee, Shou-Dong
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Taipei Vet Gen Hosp, Div Gastroenterol, Dept Med, Taipei, Taiwan
Natl Yang Ming Univ, Sch Med, Taipei 112, TaiwanTaipei Vet Gen Hosp, Div Gastroenterol, Dept Med, Taipei, Taiwan
机构:
King Saud Univ, Dept Biochem, Coll Sci, Riyadh 11495, Saudi ArabiaKing Saud Univ, Dept Biochem, Coll Sci, Riyadh 11495, Saudi Arabia
Zargar, Seema
Wani, Tanveer A.
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King Saud Univ, Dept Pharmaceut Chem, Coll Pharm, Riyadh, Saudi ArabiaKing Saud Univ, Dept Biochem, Coll Sci, Riyadh 11495, Saudi Arabia
Wani, Tanveer A.
Alamro, Abir Abdullah
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King Saud Univ, Dept Biochem, Coll Sci, Riyadh 11495, Saudi ArabiaKing Saud Univ, Dept Biochem, Coll Sci, Riyadh 11495, Saudi Arabia
Alamro, Abir Abdullah
Ganaie, Majid Ahmad
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Prince Sattam Bin Abdulaziz Univ, Dept Pharmacol, Coll Pharm, Al Kharj, Saudi ArabiaKing Saud Univ, Dept Biochem, Coll Sci, Riyadh 11495, Saudi Arabia
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Sichuan Univ, West China Sch Publ Hlth, Dept Nutr & Food Hyg, Chengdu 610041, Sichuan, Peoples R China
Sichuan Univ, West China Hosp 4, Chengdu 610041, Sichuan, Peoples R ChinaSichuan Univ, West China Sch Publ Hlth, Dept Nutr & Food Hyg, Chengdu 610041, Sichuan, Peoples R China
Zhou, Zhengming
Li, Ke
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Sichuan Univ, West China Hosp, Dept Clin Nutr, Chengdu 610041, Sichuan, Peoples R ChinaSichuan Univ, West China Sch Publ Hlth, Dept Nutr & Food Hyg, Chengdu 610041, Sichuan, Peoples R China
Li, Ke
Guo, Jiankui
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Sichuan Univ, West China Sch Publ Hlth, Dept Nutr & Food Hyg, Chengdu 610041, Sichuan, Peoples R China
Sichuan Univ, West China Hosp 4, Chengdu 610041, Sichuan, Peoples R ChinaSichuan Univ, West China Sch Publ Hlth, Dept Nutr & Food Hyg, Chengdu 610041, Sichuan, Peoples R China
Guo, Jiankui
Wang, Yunfeng
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Sichuan Univ, West China Sch Publ Hlth, Dept Nutr & Food Hyg, Chengdu 610041, Sichuan, Peoples R China
Sichuan Univ, West China Hosp 4, Chengdu 610041, Sichuan, Peoples R ChinaSichuan Univ, West China Sch Publ Hlth, Dept Nutr & Food Hyg, Chengdu 610041, Sichuan, Peoples R China
Wang, Yunfeng
Wei, Yaoyao
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Sichuan Univ, West China Sch Publ Hlth, Dept Nutr & Food Hyg, Chengdu 610041, Sichuan, Peoples R China
Sichuan Univ, West China Hosp 4, Chengdu 610041, Sichuan, Peoples R ChinaSichuan Univ, West China Sch Publ Hlth, Dept Nutr & Food Hyg, Chengdu 610041, Sichuan, Peoples R China
Wei, Yaoyao
Duan, Juan
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Sichuan Univ, West China Sch Publ Hlth, Dept Nutr & Food Hyg, Chengdu 610041, Sichuan, Peoples R China
Sichuan Univ, West China Hosp 4, Chengdu 610041, Sichuan, Peoples R ChinaSichuan Univ, West China Sch Publ Hlth, Dept Nutr & Food Hyg, Chengdu 610041, Sichuan, Peoples R China
Duan, Juan
Chen, Muxi
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Sichuan Univ, West China Hosp, Dept Clin Nutr, Chengdu 610041, Sichuan, Peoples R ChinaSichuan Univ, West China Sch Publ Hlth, Dept Nutr & Food Hyg, Chengdu 610041, Sichuan, Peoples R China
Chen, Muxi
Shi, Lei
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Sichuan Univ, West China Hosp, Dept Clin Nutr, Chengdu 610041, Sichuan, Peoples R ChinaSichuan Univ, West China Sch Publ Hlth, Dept Nutr & Food Hyg, Chengdu 610041, Sichuan, Peoples R China
Shi, Lei
Hu, Wen
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Sichuan Univ, West China Hosp, Dept Clin Nutr, Chengdu 610041, Sichuan, Peoples R ChinaSichuan Univ, West China Sch Publ Hlth, Dept Nutr & Food Hyg, Chengdu 610041, Sichuan, Peoples R China