Catalytic Enantioselective Protonation/Nucleophilic Addition of Diazoesters with Chiral Oxazaborolidinium Ion Activated Carboxylic Acids

被引：20

作者：

Kang, Ki-Tae ^{[1
,2
]}

Kim, Seung Tae ^{[2
]}

Hwang, Geum-Sook ^{[1
]}

Ryu, Do Hyun ^{[2
]}

机构：

[1] Western Seoul Ctr, Korea Basic Sci Inst, 150,Bugahyeon ro, Seoul 03759, South Korea

[2] Sungkyunkwan Univ, Dept Chem, 300,Cheoncheon, Suwon 16419, South Korea

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2017年 / 56卷 / 14期

基金：

新加坡国家研究基金会;

关键词：

asymmetric catalysis; boron; Bronsted acid; diazo compounds; reaction mechanisms; ASYMMETRIC ROSKAMP REACTION; H INSERTION REACTIONS; TROPIC ACID; KINETIC RESOLUTION; ETHYL-ESTER; PROTONATION; BOND; DERIVATIVES; CYCLOADDITIONS; MIGRATION;

D O I：

10.1002/anie.201612655

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new chiral Bronsted acid derived from carboxylic acid and a chiral oxazaborolidinium ion (COBI), as an activator, is introduced. This acid was successfully applied as a catalyst for the highly enantioselective protonation/nucleophilic addition of diazoesters with carboxylic acids.

引用

页码：3977 / 3981

页数：5

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