Obesity: An emerging driver of head and neck cancer

被引：34

作者：

Wang, Ke ^{[1
,2
,3
]}

Yu, Xiang-hua ^{[1
,2
,3
]}

Tang, Ya-Jie ^{[4
,5
]}

Tang, Ya-ling ^{[1
,2
,6
]}

Liang, Xin-hua ^{[1
,2
,3
]}

机构：

[1] Sichuan Univ, State Key Lab Oral Dis, West China Hosp Stomatol, Chengdu 610041, Sichuan, Peoples R China

[2] Sichuan Univ, Natl Clin Res Ctr Oral Dis, West China Hosp Stomatol, Chengdu 610041, Sichuan, Peoples R China

[3] Sichuan Univ, Dept Oral & Maxillofacial Surg, West China Hosp Stomatol, Chengdu 610041, Sichuan, Peoples R China

[4] Shandong Univ, State Key Lab Microbial Technol, Qingdao 266237, Shandong, Peoples R China

[5] Hubei Univ Technol, Hubei Key Lab Ind Microbiol, Hubei Prov Cooperat Innovat Ctr Ind Fermentat, Key Lab Fermentat Engn,Minist Educ, Wuhan 430068, Hubei, Peoples R China

[6] Sichuan Univ, Dept Oral Pathol, West China Hosp Stomatol, Chengdu 610041, Sichuan, Peoples R China

来源：

LIFE SCIENCES | 2019年 / 233卷

基金：

中国国家自然科学基金;

关键词：

Head and neck cancer; Obesity; Lipid metabolism; Oncology; SQUAMOUS-CELL CARCINOMA; FATTY-ACID SYNTHASE; BODY-MASS INDEX; BINDING PROTEIN; DIETARY PATTERNS; LEPTIN RECEPTOR; ADIPOSE-TISSUE; CIRCULATING ADIPONECTIN; DIFFERENTIAL EXPRESSION; INSULIN-RESISTANCE;

D O I：

10.1016/j.lfs.2019.116687

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Obesity has become pandemic and emerged as one of the most critical global health care problems worldwide since last century. Recent studies have demonstrated that there may be a causal link between obesity and higher risks and mortality of cancers, including prostate, breast, colon, and thyroid cancers, head and neck cancer (HNC). This review focuses on the relationship between obesity and HNC, and the molecular mechanism of abnormal lipid metabolism in HNC. Elucidating the mechanism may open up new possibilities for strategies to reduce risk and mortality of HNC in an increasingly obese population.

引用

页数：7

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