What MAN1 does to the smads -: TGFβ/BMP signaling and the nuclear envelope

被引:40
作者
Bengtsson, Luiza [1 ]
机构
[1] Free Univ Berlin, Inst Chem & Biochem, D-14195 Berlin, Germany
关键词
BMP; laminopathy; MAN1; nuclear envelope; phosphatase; signal transduction; Smad; TGF beta; TO-AUTOINTEGRATION FACTOR; MEMBRANE PROTEIN MAN1; RNA-RECOGNITION MOTIF; LEM-DOMAIN PROTEIN; A-TYPE LAMINS; DEPENDENT LOCALIZATION; MUSCULAR-DYSTROPHY; INTEGRAL PROTEIN; GENE-EXPRESSION; EMERIN;
D O I
10.1111/j.1742-4658.2007.05696.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The inner nuclear membrane protein MAN1 has been identified as an important factor in transforming growth factor beta/bone morphogenic protein (TGF beta/BMP) signaling. Loss of MAN1 results in three autosomal dominant diseases in humans; all three characterized by increased bone density. Xenopus embryos lacking MAN1 develop severe morphological defects. Both in humans and in Xenopus embryos the defects originate from deregulation of TGF beta/BMP signaling. Several independent studies have shown that MAN1 is antagonizing TGF beta/BMP signaling through binding to regulatory Smads. Here, recent progress in understanding MAN1 functions is summarized and a model for MAN1-dependent regulation of TGF beta/BMP signaling is proposed.
引用
收藏
页码:1374 / 1382
页数:9
相关论文
共 70 条
[61]  
Wagner N, 2006, EUR J CELL BIOL, V85, P91, DOI 10.1016/j.ejcb.2005.10.002
[62]   Two novel LEM-domain proteins are splice products of the annotated Drosophila metanogaster gene CG9424 (Bocksbeutel) [J].
Wagner, N ;
Schmitt, J ;
Krohne, G .
EUROPEAN JOURNAL OF CELL BIOLOGY, 2004, 82 (12) :605-616
[63]   The nuclear envelope, muscular dystrophy and gene expression [J].
Wilson, KL .
TRENDS IN CELL BIOLOGY, 2000, 10 (04) :125-129
[64]   Structural analysis of emerin, an inner nuclear membrane protein mutated in X-linked Emery-Dreifuss muscular dystrophy [J].
Wolff, N ;
Gilquin, B ;
Courchay, K ;
Callebaut, I ;
Worman, HJ ;
Zinn-Justin, S .
FEBS LETTERS, 2001, 501 (2-3) :171-176
[65]   Inner nuclear membrane and regulation of Smad-mediated signaling [J].
Worman, Howard J. .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2006, 1761 (5-6) :626-631
[66]  
Wu W, 2002, J CELL SCI, V115, P1361
[67]   Hierarchical model of gene regulation by transforming growth factor β [J].
Yang, YC ;
Piek, E ;
Zavadil, J ;
Liang, D ;
Xie, DL ;
Heyer, J ;
Pavlidis, P ;
Kucherlapati, R ;
Roberts, AB ;
Böttinger, EP .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (18) :10269-10274
[68]   Emerin, deficiency of which causes Emery-Dreifuss muscular dystrophy, is localized at the inner nuclear membrane [J].
Yorifuji, H ;
Tadano, Y ;
Tsuchiya, Y ;
Ogawa, M ;
Goto, K ;
Umetani, A ;
Asaka, Y ;
Arahata, K .
NEUROGENETICS, 1997, 1 (02) :135-140
[69]   Proteins that bind A-type lamins: integrating isolated clues [J].
Zastrow, MS ;
Vlcek, S ;
Wilson, KL .
JOURNAL OF CELL SCIENCE, 2004, 117 (07) :979-987
[70]   Nesprin-2 is a multi-isomeric protein that binds lamin and emerin at the nuclear envelope and forms a subcellular network in skeletal muscle [J].
Zhang, QP ;
Ragnauth, CD ;
Skepper, JN ;
Worth, NF ;
Warren, DT ;
Roberts, RG ;
Weissberg, PL ;
Ellis, JA ;
Shanahan, CM .
JOURNAL OF CELL SCIENCE, 2005, 118 (04) :673-687