RAFT controlled synthesis of six-armed biodegradable star polymeric architectures via a 'core-first' methodology

被引：48

作者：

Liu, Jingquan ^{[1
]}

Tao, Lei ^{[1
]}

Xu, Jiangtao ^{[1
]}

Jia, Zhongfan ^{[1
]}

Boyer, Cyrille ^{[1
]}

Davis, Thomas P. ^{[1
]}

机构：

[1] Univ New S Wales, CAMD, Sch Chem Sci & Engn, Sydney, SW 2052, Australia

来源：

POLYMER | 2009年 / 50卷 / 19期

基金：

澳大利亚研究理事会;

关键词：

RAFT; Star polymer; Biodegradable polymer; FRAGMENTATION CHAIN-TRANSFER; MEDIATED RADICAL POLYMERIZATION; CYCLODEXTRIN CORES; BLOCK-COPOLYMERS; TRANSFER AGENTS; COMBINATION; DESIGN; ATRP; GLUTATHIONE; INITIATION;

D O I：

10.1016/j.polymer.2009.07.018

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Six-armed biodegradable star polymers made from polystyrene (polySt), poly(polyethylene glycol) acrylate (polyPEG-A) and the block copolymer, polySt-b-polyPEG-A were synthesized using a 'core-first' methodology via RAFT polymerization. Disulfide linkages between the core and the arms conferred biodegradability on the stars. The star architectures were found to degrade rapidly on treatment with DL-dithiothreitol (DTT) and degrade more slowly in the presence of glutathione (GSH), the most abundant intracellular thiol tethered peptide. These star polymers were well characterized using gel permeation chromatography (GPC), nuclear magnetic resonance (NMR), electrospray ionization mass spectroscopy (ESI-MS) and dynamic light scattering (DLS). (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：4455 / 4463

页数：9

共 60 条

[11] Synthesis of amphiphilic miktoarm ABC star copolymers by RAFT mechanism using maleic anhydride as linking agent
Feng, XS
Pan, CY
[J]. MACROMOLECULES, 2002, 35 (13) : 4888 - 4893
[12] Influence of molecular topology on the static and dynamic properties of single polymer chain in solution
Fu, Cuiliu
Ouyang, Wenze
Sun, Zhaoyan
Ana, Lijia
[J]. JOURNAL OF CHEMICAL PHYSICS, 2007, 127 (04)
[13] Tuning the hydrophilicity of gold nanoparticles templated in star block copolymers
Fustin, Charles-Andre
Colard, Catheline
Filali, Mariam
Guillet, Pierre
Duwez, Anne-Sophie
Meier, Michael A. R.
Schubert, Ulrich S.
Gohy, Jean-Francois
[J]. LANGMUIR, 2006, 22 (15) : 6690 - 6695
[14] Hyperbranched polymers: from synthesis to applications
Gao, C
Yan, D
[J]. PROGRESS IN POLYMER SCIENCE, 2004, 29 (03) : 183 - 275
[15] Arm-first method as a simple and general method for synthesis of miktoarm star copolymers
Gao, Haifeng
Matyjaszewski, Krzysztof
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (38) : 11828 - 11834
[16] Synthesis of miktoarm star polymers via ATRP using the "in-out" method: Determination of initiation efficiency of star macroinitiators
Gao, Haifeng
Matyjaszewski, Krzysztof
[J]. MACROMOLECULES, 2006, 39 (21) : 7216 - 7223
[17] Structural control in ATRP synthesis of star polymers using the arm-first method
Gao, HF
Matyjaszewski, K
[J]. MACROMOLECULES, 2006, 39 (09) : 3154 - 3160
[18] Polymers with complex architecture by living anionic polymerization
Hadjichristidis, N
Pitsikalis, M
Pispas, S
Iatrou, H
[J]. CHEMICAL REVIEWS, 2001, 101 (12) : 3747 - 3792
[19] Dendrimers as scaffolds for multifunctional reversible addition-fragmentation chain transfer agents:: Syntheses and polymerization
Hao, XJ
Nilsson, C
Jesberger, M
Stenzel, MH
Malmström, E
Davis, TP
Östmark, E
Barner-Kowollik, C
[J]. JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 2004, 42 (23) : 5877 - 5890
[20] New polymer synthesis by nitroxide mediated living radical polymerizations
Hawker, CJ
Bosman, AW
Harth, E
[J]. CHEMICAL REVIEWS, 2001, 101 (12) : 3661 - 3688

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