RAFT controlled synthesis of six-armed biodegradable star polymeric architectures via a 'core-first' methodology

被引：48
作者：
Liu, Jingquan [1 ]
Tao, Lei [1 ]
Xu, Jiangtao [1 ]
Jia, Zhongfan [1 ]
Boyer, Cyrille [1 ]
Davis, Thomas P. [1 ]
机构：
[1] Univ New S Wales, CAMD, Sch Chem Sci & Engn, Sydney, SW 2052, Australia
来源：
POLYMER | 2009年 / 50卷 / 19期
基金：
澳大利亚研究理事会;
关键词：
RAFT; Star polymer; Biodegradable polymer; FRAGMENTATION CHAIN-TRANSFER; MEDIATED RADICAL POLYMERIZATION; CYCLODEXTRIN CORES; BLOCK-COPOLYMERS; TRANSFER AGENTS; COMBINATION; DESIGN; ATRP; GLUTATHIONE; INITIATION;
D O I：
10.1016/j.polymer.2009.07.018
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Six-armed biodegradable star polymers made from polystyrene (polySt), poly(polyethylene glycol) acrylate (polyPEG-A) and the block copolymer, polySt-b-polyPEG-A were synthesized using a 'core-first' methodology via RAFT polymerization. Disulfide linkages between the core and the arms conferred biodegradability on the stars. The star architectures were found to degrade rapidly on treatment with DL-dithiothreitol (DTT) and degrade more slowly in the presence of glutathione (GSH), the most abundant intracellular thiol tethered peptide. These star polymers were well characterized using gel permeation chromatography (GPC), nuclear magnetic resonance (NMR), electrospray ionization mass spectroscopy (ESI-MS) and dynamic light scattering (DLS). (C) 2009 Elsevier Ltd. All rights reserved.
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收藏
页码：4455 / 4463
页数：9
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