Determination of the Lipophilicity of Twenty-Seven Imidazo[2,1-c][1,2,4]triazine Derivatives with Strong Biological Activity by Reversed-Phase TLC. Comparison with Results Obtained by Use of Computational Algorithms

被引：4

作者：

Komsta, Lukasz ^{[1
]}

Sztanke, Krzysztof ^{[2
]}

Maczka, Paulina ^{[1
]}

Ucherek, Marzena ^{[3
]}

Skibinski, Robert ^{[1
]}

Gumieniczek, Anna ^{[1
]}

机构：

[1] Med Univ Lublin, Dept Med Chem, Fac Pharm, PL-20090 Lublin, Poland

[2] Med Univ Lublin, Dept Med Chem, Fac Med, PL-20081 Lublin, Poland

[3] Nicholas Copernicus Univ Torun, Dept Organ Chem, Fac Pharm, PL-85094 Bydgoszcz, Poland

来源：

JPC-JOURNAL OF PLANAR CHROMATOGRAPHY-MODERN TLC | 2009年 / 22卷 / 05期

关键词：

Imidazotriazines; Imidazo[2,1-c][1,2,4]triazine; Lipophilicity; LIQUID-CHROMATOGRAPHY; CARBONYL DERIVATIVES; CHEMISTRY;

D O I：

10.1556/JPC.22.2009.5.3

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The lipophilicity, log P, of 27 novel imidazo[2,1-c][1,2,4]triazine derivatives with strong biological activity has been determined by reversed-phase thin-layer chromatography. The compounds were chromatographed on RP18 plates with methanol-water binary mobile phases containing different proportions of methanol. R(M) values for pure water were then extrapolated from the linear Soczewinski-Wachtmeister equation. Twelve compounds with known literature log P values acted as a reference calibration data set for computation of experimental log P values. The results obtained were compared, by principal-components analysis, with those obtained by use of nine computational methods.

引用

页码：327 / 331

页数：5

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