Studies with Azinylacetonitriles: 2-Pyridylacetonitrile as a Precursor to Functionally Substituted Pyridines

被引：5

作者：

Al-Sheikh, Mariam Abdullah ^{[1
]}

Elnagdi, Mohamed Hilmy ^{[2
]}

机构：

[1] Girls Coll Educ, Dept Chem, Jeddah 21323, Saudi Arabia

[2] Kuwait Univ, Fac Sci, Dept Chem, Kuwait, Kuwait

来源：

MOLECULES | 2009年 / 14卷 / 11期

关键词：

2-pyridylacetonitrile; enaminonitrile; arylhydrazones; HETEROCYCLIC SYNTHESIS; 2-ARYLHYDRAZONONITRILES; AZOLES; ROUTE;

D O I：

10.3390/molecules14114406

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

2-Pyridylacetonitrile (1) couples with aromatic diazonium salts to yield arylhydrazones 2a-c, that were shown to exist in the syn-form 2 rather than the anti-form 4. Compounds 2a, c reacted with hydroxylamine in refluxing DMF to yield the interesting 1,2,3-triazolylpyridines 6. Attempts to cyclize 2 to give the corresponding fused pyrazolopyridines 9 failed. On the other hand, compound 1 condensed with dimethylformamide dimethyl acetal to yield enaminonitrile 10 that could be converted into pyrazolylpyridine 11.

引用

页码：4406 / 4413

页数：8

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