Back to the future: application of contemporary technology to long-standing questions about the clinical relevance of human leukocyte antigen-specific alloantibodies in renal transplantation

被引：59
作者：
Taylor, Craig J. [1 ]
Kosmoliaptsis, Vasilis [1 ,2 ]
Summers, Dominic M. [1 ,2 ]
Bradley, J. Andrew [2 ]
机构：
[1] Cambridge Univ Hosp NHS Fdn Trust, Addenbrookes Hosp, Tissue Typing Lab, Cambridge CB2 0QQ, England
[2] Univ Cambridge, Addenbrookes Hosp, Dept Surg, Cambridge CB2 0QQ, England
来源：
HUMAN IMMUNOLOGY | 2009年 / 70卷 / 08期
关键词：
Kidney transplantation; HLA-specific antibodies; Allosensitization; Donor cross-match; Luminex; Single-antigen-beads; HLA CLASS-I; HIGHLY SENSITIZED PATIENTS; CELL CROSS-MATCHES; POSITIVE T-CELL; FLOW-CYTOMETRY; KIDNEY-TRANSPLANTATION; LYMPHOCYTOTOXIC ANTIBODIES; ALLOGRAFT RECIPIENTS; IMMUNOGLOBULIN-G; REJECTION;
D O I：
10.1016/j.humimm.2009.05.001
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Luminex technology allows the accurate identification of human leukocyte antigen (HLA) class I and class II-specific antibodies at levels below the threshold detectable by either conventional complement-dependent lymphocytotoxicity or flow cytometry. The technology enables the analysis of complex antibody profiles in sensitized patients and gives improved definition of acceptable and unacceptable HLA specificities to guide donor kidney allocation. This helps to facilitate virtual cross-matching and avoid inappropriate shipping of kidneys for incompatible patients in distant centers. Luminex allows the cause of a positive cross-match test to be determined in a clinically relevant time scale and, when used in conjunction with lymphocytotoxic and flow cytometric cross-matching, it provides an assessment of the level of immunological risk in patients being considered as potential recipients for a particular donor kidney. information is now emerging to enable the full clinical potential of Luminex to be realized. (C) 2009 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
引用
收藏
页码：563 / 568
页数：6
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