Cholinergic signaling in myelination

被引:47
作者
Fields, R. Douglas [1 ]
Dutta, Dipankar J. [1 ,2 ]
Belgrad, Jillian [1 ]
Robnett, Maya [1 ]
机构
[1] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Nervous Syst Dev & Plast Sect, NIH, Bethesda, MD USA
[2] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA
关键词
acetylcholine (ACh); acetylcholinesterase (AChE); muscarinic receptors; butyrylcholinesterase (BChE); nicotinic receptors; organophosphates; MUSCARINIC RECEPTOR SUBTYPES; RESCUES BEHAVIORAL-CHANGES; SQUID NERVE-FIBER; SCHWANN-CELL; CHOLINESTERASE ACTIVITY; WHITE-MATTER; ACETYLCHOLINE-RECEPTORS; CEREBRAL HYPOPERFUSION; MULTIPLE-SCLEROSIS; BENZILATE BINDING;
D O I
10.1002/glia.23101
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
There is a long history of research on acetylcholine (ACh) function in myelinating glia, but a resurgence of interest recently as a result of the therapeutic potential of manipulating ACh signaling to promote remyelination, and the broader interest in neurotransmitter signaling in activity-dependent myelination. Myelinating glia express all the major types of muscarinic and nicotinic ACh receptors at different stages of development, and acetylcholinesterase and butyrylcholinesterase are highly expressed in white matter. This review traces the history of research on ACh signaling in Schwann cells, oligodendrocytes, and in the myelin sheath, and summarizes current knowledge on the intracellular signaling and functional consequences of ACh signaling in myelinating glia. Implications of ACh in diseases, such as Alzheimer's disease, multiple sclerosis, and white matter toxicity caused by pesticides are considered, together with an outline of major questions for future research.
引用
收藏
页码:687 / 698
页数:12
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