共 56 条
Synergistic roles of p53 and HIF1α in human renal cell carcinoma-cell apoptosis responding to the inhibition of mTOR and MDM2 signaling pathways
被引:11
作者:

Liu, Qing-jun
论文数: 0 引用数: 0
h-index: 0
机构:
Capital Med Univ, Dept Urol Surg, Beijing Friendship Hosp, 95 Yongan Rd, Beijing 100050, Peoples R China Capital Med Univ, Dept Urol Surg, Beijing Friendship Hosp, 95 Yongan Rd, Beijing 100050, Peoples R China

Shen, Hong-liang
论文数: 0 引用数: 0
h-index: 0
机构:
Capital Med Univ, Dept Urol Surg, Beijing Friendship Hosp, 95 Yongan Rd, Beijing 100050, Peoples R China Capital Med Univ, Dept Urol Surg, Beijing Friendship Hosp, 95 Yongan Rd, Beijing 100050, Peoples R China

Lin, Jun
论文数: 0 引用数: 0
h-index: 0
机构:
Capital Med Univ, Dept Urol Surg, Beijing Friendship Hosp, 95 Yongan Rd, Beijing 100050, Peoples R China Capital Med Univ, Dept Urol Surg, Beijing Friendship Hosp, 95 Yongan Rd, Beijing 100050, Peoples R China

Xu, Xiu-hong
论文数: 0 引用数: 0
h-index: 0
机构:
Capital Med Univ, Dept Urol Surg, Beijing Friendship Hosp, 95 Yongan Rd, Beijing 100050, Peoples R China Capital Med Univ, Dept Urol Surg, Beijing Friendship Hosp, 95 Yongan Rd, Beijing 100050, Peoples R China

Ji, Zheng-guo
论文数: 0 引用数: 0
h-index: 0
机构:
Capital Med Univ, Dept Urol Surg, Beijing Friendship Hosp, 95 Yongan Rd, Beijing 100050, Peoples R China Capital Med Univ, Dept Urol Surg, Beijing Friendship Hosp, 95 Yongan Rd, Beijing 100050, Peoples R China

Han, Xiao
论文数: 0 引用数: 0
h-index: 0
机构:
Capital Med Univ, Dept Urol Surg, Beijing Friendship Hosp, 95 Yongan Rd, Beijing 100050, Peoples R China Capital Med Univ, Dept Urol Surg, Beijing Friendship Hosp, 95 Yongan Rd, Beijing 100050, Peoples R China

Shang, Dong-hao
论文数: 0 引用数: 0
h-index: 0
机构:
Capital Med Univ, Dept Urol Surg, Beijing Friendship Hosp, 95 Yongan Rd, Beijing 100050, Peoples R China Capital Med Univ, Dept Urol Surg, Beijing Friendship Hosp, 95 Yongan Rd, Beijing 100050, Peoples R China

Yang, Pei-qian
论文数: 0 引用数: 0
h-index: 0
机构:
Capital Med Univ, Dept Urol Surg, Beijing Friendship Hosp, 95 Yongan Rd, Beijing 100050, Peoples R China Capital Med Univ, Dept Urol Surg, Beijing Friendship Hosp, 95 Yongan Rd, Beijing 100050, Peoples R China
机构:
[1] Capital Med Univ, Dept Urol Surg, Beijing Friendship Hosp, 95 Yongan Rd, Beijing 100050, Peoples R China
基金:
中国国家自然科学基金;
关键词:
renal cell carcinoma;
mTOR;
MDM2;
p53;
HIF1;
alpha;
apoptosis;
DUAL PI3K/MTOR INHIBITOR;
MAMMALIAN TARGET;
MITOCHONDRIAL APOPTOSIS;
MEDIATED APOPTOSIS;
CANCER-CELLS;
RAPAMYCIN;
PROTEIN;
THERAPY;
COMBINATION;
PROGRESSION;
D O I:
10.2147/DDDT.S88779
中图分类号:
R914 [药物化学];
学科分类号:
100701 ;
摘要:
Introduction: mTOR and MDM2 signaling pathways are frequently deregulated in cancer development, and inhibition of mTOR or MDM2 independently enhances carcinoma-cell apoptosis. However, responses to mTOR and MDM2 antagonists in renal cell carcinoma (RCC) remain unknown. Materials and methods: A498 cells treated with MDM2 antagonist MI-319 and/or mTOR inhibitor rapamycin were employed in the present study. Cell apoptosis and Western blot analysis were performed. Results and conclusion: We found that the MDM2 inhibitor MI-319 induced RCC cell apoptosis mainly dependent on p53 overexpression, while the mTOR antagonist rapamycin promoted RCC cell apoptosis primarily through upregulation of HIF1 alpha expression. Importantly, strong synergistic effects of MI-319 and rapamycin combinations at relatively low concentrations on RCC cell apoptosis were observed. Depletion of p53 or HIF1 alpha impaired both antagonist-elicited apoptoses to differential extents, corresponding to their expression changes responding to chemical treatments, and double knockdown of p53 and HIF1 alpha remarkably hindered MI-319- or rapamycin-induced apoptosis, suggesting that both p53 and HIF1 alpha are involved in MDM2 or mTOR antagonist-induced apoptosis. Collectively, we propose that concurrent activation of p53 and HIF1a may effectively result in cancer-cell apoptosis, and that combined MDM2 antagonists and mTOR inhibitors may be useful in RCC therapy.
引用
收藏
页码:745 / 755
页数:11
相关论文
共 56 条
[1]
Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma
[J].
Atkins, MB
;
Hidalgo, M
;
Stadler, WM
;
Logan, TF
;
Dutcher, JP
;
Hudes, GR
;
Park, Y
;
Lion, SH
;
Marshall, B
;
Boni, JP
;
Dukart, G
;
Sherman, ML
.
JOURNAL OF CLINICAL ONCOLOGY,
2004, 22 (05)
:909-918

Atkins, MB
论文数: 0 引用数: 0
h-index: 0
机构: Beth Israel Deaconess Med Ctr, Dept Med, Div Hematol Oncol, Boston, MA 02215 USA

Hidalgo, M
论文数: 0 引用数: 0
h-index: 0
机构: Beth Israel Deaconess Med Ctr, Dept Med, Div Hematol Oncol, Boston, MA 02215 USA

Stadler, WM
论文数: 0 引用数: 0
h-index: 0
机构: Beth Israel Deaconess Med Ctr, Dept Med, Div Hematol Oncol, Boston, MA 02215 USA

Logan, TF
论文数: 0 引用数: 0
h-index: 0
机构: Beth Israel Deaconess Med Ctr, Dept Med, Div Hematol Oncol, Boston, MA 02215 USA

Dutcher, JP
论文数: 0 引用数: 0
h-index: 0
机构: Beth Israel Deaconess Med Ctr, Dept Med, Div Hematol Oncol, Boston, MA 02215 USA

Hudes, GR
论文数: 0 引用数: 0
h-index: 0
机构: Beth Israel Deaconess Med Ctr, Dept Med, Div Hematol Oncol, Boston, MA 02215 USA

Park, Y
论文数: 0 引用数: 0
h-index: 0
机构: Beth Israel Deaconess Med Ctr, Dept Med, Div Hematol Oncol, Boston, MA 02215 USA

Lion, SH
论文数: 0 引用数: 0
h-index: 0
机构: Beth Israel Deaconess Med Ctr, Dept Med, Div Hematol Oncol, Boston, MA 02215 USA

论文数: 引用数:
h-index:
机构:

Boni, JP
论文数: 0 引用数: 0
h-index: 0
机构: Beth Israel Deaconess Med Ctr, Dept Med, Div Hematol Oncol, Boston, MA 02215 USA

Dukart, G
论文数: 0 引用数: 0
h-index: 0
机构: Beth Israel Deaconess Med Ctr, Dept Med, Div Hematol Oncol, Boston, MA 02215 USA

Sherman, ML
论文数: 0 引用数: 0
h-index: 0
机构: Beth Israel Deaconess Med Ctr, Dept Med, Div Hematol Oncol, Boston, MA 02215 USA
[2]
mTOR Inhibition Induces Compensatory, Therapeutically Targetable MEK Activation in Renal Cell Carcinoma
[J].
Bailey, Sean T.
;
Zhou, Bing
;
Damrauer, Jeffrey S.
;
Krishnan, Bhavani
;
Wilson, Harper L.
;
Smith, Aleisha M.
;
Li, Mingqing
;
Yeh, Jen Jen
;
Kim, William Y.
.
PLOS ONE,
2014, 9 (09)

Bailey, Sean T.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA
Univ N Carolina, Dept Genet, Chapel Hill, NC USA Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

Zhou, Bing
论文数: 0 引用数: 0
h-index: 0
机构:
Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

Damrauer, Jeffrey S.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA
Univ N Carolina, Dept Genet, Chapel Hill, NC USA Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

Krishnan, Bhavani
论文数: 0 引用数: 0
h-index: 0
机构:
Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

Wilson, Harper L.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

Smith, Aleisha M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

Li, Mingqing
论文数: 0 引用数: 0
h-index: 0
机构:
Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

Yeh, Jen Jen
论文数: 0 引用数: 0
h-index: 0
机构:
Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA
Univ N Carolina, Dept Surg, Chapel Hill, NC USA
Univ N Carolina, Dept Pharmacol, Chapel Hill, NC USA Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

Kim, William Y.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA
Univ N Carolina, Dept Med, Chapel Hill, NC USA
Univ N Carolina, Dept Genet, Chapel Hill, NC USA Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA
[3]
mTOR activates hypoxia-inducible factor-1α and inhibits neuronal apoptosis in the developing rat brain during the early phase after hypoxia-ischemia
[J].
Chen, Hongju
;
Xiong, Tao
;
Qu, Yi
;
Zhao, Fengyan
;
Ferriero, Donna
;
Mu, Dezhi
.
NEUROSCIENCE LETTERS,
2012, 507 (02)
:118-123

Chen, Hongju
论文数: 0 引用数: 0
h-index: 0
机构:
Sichuan Univ, Dept Pediat, W China Univ Hosp 2, Chengdu 610041, Sichuan, Peoples R China
Sichuan Univ, Key Lab Obstet & Gynecol & Pediat Dis & Birth Def, Minist Educ, Chengdu 610041, Sichuan, Peoples R China Sichuan Univ, Dept Pediat, W China Univ Hosp 2, Chengdu 610041, Sichuan, Peoples R China

Xiong, Tao
论文数: 0 引用数: 0
h-index: 0
机构:
Sichuan Univ, Dept Pediat, W China Univ Hosp 2, Chengdu 610041, Sichuan, Peoples R China
Sichuan Univ, Key Lab Obstet & Gynecol & Pediat Dis & Birth Def, Minist Educ, Chengdu 610041, Sichuan, Peoples R China Sichuan Univ, Dept Pediat, W China Univ Hosp 2, Chengdu 610041, Sichuan, Peoples R China

Qu, Yi
论文数: 0 引用数: 0
h-index: 0
机构:
Sichuan Univ, Dept Pediat, W China Univ Hosp 2, Chengdu 610041, Sichuan, Peoples R China
Sichuan Univ, Key Lab Obstet & Gynecol & Pediat Dis & Birth Def, Minist Educ, Chengdu 610041, Sichuan, Peoples R China Sichuan Univ, Dept Pediat, W China Univ Hosp 2, Chengdu 610041, Sichuan, Peoples R China

Zhao, Fengyan
论文数: 0 引用数: 0
h-index: 0
机构:
Sichuan Univ, Dept Pediat, W China Univ Hosp 2, Chengdu 610041, Sichuan, Peoples R China
Sichuan Univ, Key Lab Obstet & Gynecol & Pediat Dis & Birth Def, Minist Educ, Chengdu 610041, Sichuan, Peoples R China Sichuan Univ, Dept Pediat, W China Univ Hosp 2, Chengdu 610041, Sichuan, Peoples R China

Ferriero, Donna
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA Sichuan Univ, Dept Pediat, W China Univ Hosp 2, Chengdu 610041, Sichuan, Peoples R China

Mu, Dezhi
论文数: 0 引用数: 0
h-index: 0
机构:
Sichuan Univ, Dept Pediat, W China Univ Hosp 2, Chengdu 610041, Sichuan, Peoples R China
Sichuan Univ, Key Lab Obstet & Gynecol & Pediat Dis & Birth Def, Minist Educ, Chengdu 610041, Sichuan, Peoples R China
Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA Sichuan Univ, Dept Pediat, W China Univ Hosp 2, Chengdu 610041, Sichuan, Peoples R China
[4]
PKB/Akt Activation Inhibits p53-Mediated HIF1A Degradation That Is Independent of MDM2
[J].
Choy, Mun-Kit
;
Movassagh, Mehregan
;
Bennett, Martin R.
;
Foo, Roger S. -Y.
.
JOURNAL OF CELLULAR PHYSIOLOGY,
2010, 222 (03)
:635-639

Choy, Mun-Kit
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Cambridge, Addenbrookes Hosp, Dept Med, Cambridge CB2 20QQ, England Univ Cambridge, Addenbrookes Hosp, Dept Med, Cambridge CB2 20QQ, England

Movassagh, Mehregan
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Cambridge, Addenbrookes Hosp, Dept Med, Cambridge CB2 20QQ, England Univ Cambridge, Addenbrookes Hosp, Dept Med, Cambridge CB2 20QQ, England

Bennett, Martin R.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Cambridge, Addenbrookes Hosp, Dept Med, Cambridge CB2 20QQ, England Univ Cambridge, Addenbrookes Hosp, Dept Med, Cambridge CB2 20QQ, England

Foo, Roger S. -Y.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Cambridge, Addenbrookes Hosp, Dept Med, Cambridge CB2 20QQ, England Univ Cambridge, Addenbrookes Hosp, Dept Med, Cambridge CB2 20QQ, England
[5]
Prolonged efficacy of mTOR inhibitors in papillary renal cell carcinoma: progression-free survival lasting for over 3 years, a case report and review of the literature
[J].
Daste, Amaury
;
Gross-Goupil, Marine
;
Roca, Sophie
;
Bernhard, Jean-Christophe
;
Ravaud, Alain
.
TARGETED ONCOLOGY,
2014, 9 (01)
:81-84

Daste, Amaury
论文数: 0 引用数: 0
h-index: 0
机构:
Hop St Andre, Dept Med Oncol, F-33000 Bordeaux, France
CHU Bordeaux, Univ Hosp, F-33000 Bordeaux, France Hop St Andre, Dept Med Oncol, F-33000 Bordeaux, France

Gross-Goupil, Marine
论文数: 0 引用数: 0
h-index: 0
机构:
Hop St Andre, Dept Med Oncol, F-33000 Bordeaux, France
CHU Bordeaux, Univ Hosp, F-33000 Bordeaux, France Hop St Andre, Dept Med Oncol, F-33000 Bordeaux, France

Roca, Sophie
论文数: 0 引用数: 0
h-index: 0
机构:
Hop St Andre, Dept Med Oncol, F-33000 Bordeaux, France
CHU Bordeaux, Univ Hosp, F-33000 Bordeaux, France Hop St Andre, Dept Med Oncol, F-33000 Bordeaux, France

Bernhard, Jean-Christophe
论文数: 0 引用数: 0
h-index: 0
机构:
CHU Bordeaux, Univ Hosp, F-33000 Bordeaux, France
Hop Pellegrin, Dept Urol, F-33076 Bordeaux, France Hop St Andre, Dept Med Oncol, F-33000 Bordeaux, France

Ravaud, Alain
论文数: 0 引用数: 0
h-index: 0
机构:
Hop St Andre, Dept Med Oncol, F-33000 Bordeaux, France
CHU Bordeaux, Univ Hosp, F-33000 Bordeaux, France
Univ Bordeaux 2 Victor Segalen, Bordeaux, France
INSERM 005, CIC, Bordeaux, France Hop St Andre, Dept Med Oncol, F-33000 Bordeaux, France
[6]
The loss of mdm2 induces p53 mediated apoptosis
[J].
de Rozieres, S
;
Maya, R
;
Oren, M
;
Lozano, G
.
ONCOGENE,
2000, 19 (13)
:1691-1697

de Rozieres, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, MD Anderson Canc Ctr, Dept Mol Genet, Houston, TX 77030 USA

Maya, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, MD Anderson Canc Ctr, Dept Mol Genet, Houston, TX 77030 USA

Oren, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, MD Anderson Canc Ctr, Dept Mol Genet, Houston, TX 77030 USA

Lozano, G
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, MD Anderson Canc Ctr, Dept Mol Genet, Houston, TX 77030 USA
[7]
EGFR protein overexpression correlates with chromosome 7 polysomy and poor prognostic parameters in clear cell renal cell carcinoma
[J].
Dordevic, Gordana
;
Ilijas, Koviljka Matusan
;
Hadzisejdic, Ita
;
Maricic, Anton
;
Grahovac, Blazenka
;
Jonjic, Nives
.
JOURNAL OF BIOMEDICAL SCIENCE,
2012, 19

Dordevic, Gordana
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Rijeka, Sch Med, Dept Pathol, Rijeka 51000, Croatia Univ Rijeka, Sch Med, Dept Pathol, Rijeka 51000, Croatia

Ilijas, Koviljka Matusan
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Rijeka, Sch Med, Dept Pathol, Rijeka 51000, Croatia Univ Rijeka, Sch Med, Dept Pathol, Rijeka 51000, Croatia

Hadzisejdic, Ita
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Rijeka, Sch Med, Dept Pathol, Rijeka 51000, Croatia Univ Rijeka, Sch Med, Dept Pathol, Rijeka 51000, Croatia

Maricic, Anton
论文数: 0 引用数: 0
h-index: 0
机构:
Rijeka Univ Hosp Ctr, Dept Urol, Rijeka 51000, Croatia Univ Rijeka, Sch Med, Dept Pathol, Rijeka 51000, Croatia

Grahovac, Blazenka
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Rijeka, Sch Med, Dept Pathol, Rijeka 51000, Croatia Univ Rijeka, Sch Med, Dept Pathol, Rijeka 51000, Croatia

Jonjic, Nives
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Rijeka, Sch Med, Dept Pathol, Rijeka 51000, Croatia Univ Rijeka, Sch Med, Dept Pathol, Rijeka 51000, Croatia
[8]
Targeting mTOR to Overcome Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Resistance in Non-Small Cell Lung Cancer Cells
[J].
Fei, Shi-Jiang
;
Zhang, Xu-Chao
;
Dong, Song
;
Cheng, Hua
;
Zhang, Yi-Fang
;
Huang, Ling
;
Zhou, Hai-Yu
;
Xie, Zhi
;
Chen, Zhi-Hong
;
Wu, Yi-Long
.
PLOS ONE,
2013, 8 (07)

Fei, Shi-Jiang
论文数: 0 引用数: 0
h-index: 0
机构:
Guangdong Gen Hosp, Guangdong Lung Canc Inst, Med Res Ctr, Guangzhou, Guangdong, Peoples R China
Guangdong Acad Med Sci, Guangzhou, Guangdong, Peoples R China
Southern Med Univ, Grad Sch, Guangzhou, Guangdong, Peoples R China Guangdong Gen Hosp, Guangdong Lung Canc Inst, Med Res Ctr, Guangzhou, Guangdong, Peoples R China

Zhang, Xu-Chao
论文数: 0 引用数: 0
h-index: 0
机构:
Guangdong Gen Hosp, Guangdong Lung Canc Inst, Med Res Ctr, Guangzhou, Guangdong, Peoples R China
Guangdong Acad Med Sci, Guangzhou, Guangdong, Peoples R China Guangdong Gen Hosp, Guangdong Lung Canc Inst, Med Res Ctr, Guangzhou, Guangdong, Peoples R China

Dong, Song
论文数: 0 引用数: 0
h-index: 0
机构:
Guangdong Gen Hosp, Guangdong Lung Canc Inst, Med Res Ctr, Guangzhou, Guangdong, Peoples R China
Guangdong Acad Med Sci, Guangzhou, Guangdong, Peoples R China Guangdong Gen Hosp, Guangdong Lung Canc Inst, Med Res Ctr, Guangzhou, Guangdong, Peoples R China

Cheng, Hua
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Affiliated Hosp 5, Zhuhai, Guangdong, Peoples R China Guangdong Gen Hosp, Guangdong Lung Canc Inst, Med Res Ctr, Guangzhou, Guangdong, Peoples R China

Zhang, Yi-Fang
论文数: 0 引用数: 0
h-index: 0
机构:
Guangdong Gen Hosp, Guangdong Lung Canc Inst, Med Res Ctr, Guangzhou, Guangdong, Peoples R China
Guangdong Acad Med Sci, Guangzhou, Guangdong, Peoples R China Guangdong Gen Hosp, Guangdong Lung Canc Inst, Med Res Ctr, Guangzhou, Guangdong, Peoples R China

Huang, Ling
论文数: 0 引用数: 0
h-index: 0
机构:
Guangdong Gen Hosp, Guangdong Lung Canc Inst, Med Res Ctr, Guangzhou, Guangdong, Peoples R China
Guangdong Acad Med Sci, Guangzhou, Guangdong, Peoples R China Guangdong Gen Hosp, Guangdong Lung Canc Inst, Med Res Ctr, Guangzhou, Guangdong, Peoples R China

Zhou, Hai-Yu
论文数: 0 引用数: 0
h-index: 0
机构:
Guangdong Gen Hosp, Guangdong Lung Canc Inst, Med Res Ctr, Guangzhou, Guangdong, Peoples R China
Guangdong Acad Med Sci, Guangzhou, Guangdong, Peoples R China Guangdong Gen Hosp, Guangdong Lung Canc Inst, Med Res Ctr, Guangzhou, Guangdong, Peoples R China

Xie, Zhi
论文数: 0 引用数: 0
h-index: 0
机构:
Guangdong Gen Hosp, Guangdong Lung Canc Inst, Med Res Ctr, Guangzhou, Guangdong, Peoples R China
Guangdong Acad Med Sci, Guangzhou, Guangdong, Peoples R China Guangdong Gen Hosp, Guangdong Lung Canc Inst, Med Res Ctr, Guangzhou, Guangdong, Peoples R China

Chen, Zhi-Hong
论文数: 0 引用数: 0
h-index: 0
机构:
Guangdong Gen Hosp, Guangdong Lung Canc Inst, Med Res Ctr, Guangzhou, Guangdong, Peoples R China
Guangdong Acad Med Sci, Guangzhou, Guangdong, Peoples R China Guangdong Gen Hosp, Guangdong Lung Canc Inst, Med Res Ctr, Guangzhou, Guangdong, Peoples R China

Wu, Yi-Long
论文数: 0 引用数: 0
h-index: 0
机构:
Guangdong Gen Hosp, Guangdong Lung Canc Inst, Med Res Ctr, Guangzhou, Guangdong, Peoples R China
Guangdong Acad Med Sci, Guangzhou, Guangdong, Peoples R China Guangdong Gen Hosp, Guangdong Lung Canc Inst, Med Res Ctr, Guangzhou, Guangdong, Peoples R China
[9]
The coordinate regulation of the p53 and rnTOR pathways in cells
[J].
Feng, ZH
;
Zhang, H
;
Levine, AJ
;
Jin, S
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
2005, 102 (23)
:8204-8209

Feng, ZH
论文数: 0 引用数: 0
h-index: 0
机构: Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Canc Inst New Jersey, New Brunswick, NJ 08903 USA

Zhang, H
论文数: 0 引用数: 0
h-index: 0
机构: Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Canc Inst New Jersey, New Brunswick, NJ 08903 USA

Levine, AJ
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Canc Inst New Jersey, New Brunswick, NJ 08903 USA Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Canc Inst New Jersey, New Brunswick, NJ 08903 USA

Jin, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Canc Inst New Jersey, New Brunswick, NJ 08903 USA
[10]
The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein
[J].
Feng, Zhaohui
;
Levine, Arnold J.
.
TRENDS IN CELL BIOLOGY,
2010, 20 (07)
:427-434

Feng, Zhaohui
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Med & Dent New Jersey, Canc Inst New Jersey, New Brunswick, NJ 08903 USA Univ Med & Dent New Jersey, Canc Inst New Jersey, New Brunswick, NJ 08903 USA

Levine, Arnold J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Med & Dent New Jersey, Canc Inst New Jersey, New Brunswick, NJ 08903 USA
Inst Adv Study, Princeton, NJ 08540 USA Univ Med & Dent New Jersey, Canc Inst New Jersey, New Brunswick, NJ 08903 USA