Primordial Germ Cells: Current Knowledge and Perspectives

被引：36

作者：

Nikolic, Aleksandar ^{[1
]}

Volarevic, Vladislav ^{[1
]}

Armstrong, Lyle ^{[2
]}

Lako, Majlinda ^{[2
]}

Stojkovic, Miodrag ^{[1
,3
]}

机构：

[1] Univ Kragujevac, Fac Med Sci, Ctr Mol Med & Stem Cell Res, Kragujevac 34000, Serbia

[2] Newcastle Univ, Int Ctr Life,Cent Pkwy, Inst Genet Med, Newcastle Upon Tyne NE1 3BZ, Tyne & Wear, England

[3] Spebo Med, Leskovac 16000, Serbia

来源：

STEM CELLS INTERNATIONAL | 2016年 / 2016卷

基金：

英国生物技术与生命科学研究理事会;

关键词：

PLURIPOTENT STEM-CELLS; MOUSE EMBRYO; IN-VITRO; DROSOPHILA-MELANOGASTER; SEXUAL-DIFFERENTIATION; CAENORHABDITIS-ELEGANS; MICE; SPECIFICATION; MIGRATION; GENE;

D O I：

10.1155/2016/1741072

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Infertility is a condition that occurs very frequently and understanding what defines normal fertility is crucial to helping patients. Causes of infertility are numerous and the treatment often does not lead to desired pregnancy especially when there is a lack of functional gametes. In humans, the primordial germcell (PGC) is the primary undifferentiated stem cell type that will differentiate towards gametes: spermatozoa or oocytes. With the development of stem cell biology and differentiation protocols, PGC can be obtained from pluripotent stem cells providing a new therapeutic possibility to treat infertile couples. Recent studies demonstrated that viable mouse pups could be obtained from in vitro differentiated stem cells suggesting that translation of these results to human is closer. Therefore, the aim of this review is to summarize current knowledge about PGC indicating the perspective of their use in both research and medical application for the treatment of infertility.

引用

页数：8

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