Dynamical decision making in a genetic perceptron

Decision making is an essential element of cell functioning, which determines milestones of its evolution including differentiation, apoptosis and possible transition to cancerous state. Recently the concept of stochastic resonance in decision making (SRIDM) was introduced, demonstrated and explained using a synthetic genetic classifier circuit as an example. It manifests itself as a maximum in the dependence of classification accuracy upon noise intensity, and was caused by the concurrent action of two factors, both coarsening the classification accuracy by themselves, but found to extenuate the effect of each other: perturbation of classifier threshold and additive noise in classifier inputs. In the present work we extend the SRIDM concept to dynamical decision making, in which a classifier keeps track of the changeable input. We reproduce the stochastic resonance effect caused by noise and threshold perturbation, and demonstrate a new mechanism of SRIDM, which is associated with bistability and not connected with threshold perturbation. (C) 2015 Elsevier B.V. All rights reserved.