Longitudinal analysis of serum neutralization of SARS-CoV-2 Omicron BA.2, BA.4, and BA.5 in patients receiving monoclonal antibodies

被引：45

作者：

Bruel, Timothee ^{[1
,2
]}

Stefic, Karl ^{[3
,4
]}

Nguyen, Yann ^{[5
]}

Toniutti, Donatella ^{[1
]}

Staropoli, Isabelle ^{[1
]}

Porrot, Francoise ^{[1
]}

Guivel-Benhassine, Florence ^{[1
]}

Bolland, William-Henry ^{[1
,6
]}

Planas, Delphine ^{[1
,2
]}

Hadjadj, Jerome ^{[5
]}

Handala, Lynda ^{[3
,4
]}

Planchais, Cyril ^{[7
]}

Prot, Matthieu ^{[8
]}

Simon-Loriere, Etienne ^{[8
]}

Andre, Emmanuel ^{[9
,10
]}

Baele, Guy ^{[11
]}

Cuypers, Lize ^{[9
]}

Mouthon, Luc

Mouquet, Hugo ^{[7
]}

Buchrieser, Julian ^{[1
]}

Seve, Aymeric ^{[12
]}

Prazuck, Thierry ^{[12
]}

Maes, Piet ^{[11
]}

Terrier, Benjamin

Hocqueloux, Laurent ^{[12
]}

Schwartz, Olivier ^{[1
,2
]}

机构：

[1] Univ Paris Cite, Inst Pasteur, Virus & Immun Unit, CNRS,UMR3569, Paris, France

[2] Vaccine Res Inst, Creteil, France

[3] Univ Tours, INSERM, U1259, Tours, France

[4] CHRU Tours, Natl Reference Ctr HIV, Associated Lab, Tours, France

[5] Hop Cochin, AP HP, Natl Reference Ctr Rare Syst Autoimmune Dis, Dept Internal Med,APHP CUP, Paris, France

[6] Univ Paris Cite, Ecole Doctorale BioSPC 562, Paris, France

[7] Univ Paris Cite, Inst Pasteur, Humoral Immunol Lab, INSERM,U1222, Paris, France

[8] Univ Paris Cite, Inst Pasteur, G5 Evolutionary Genom RNA Viruses, Paris, France

[9] Univ Hosp Leuven, Natl Reference Ctr Resp Pathogens, Dept Lab Med, Leuven, Belgium

[10] Katholieke Univ Leuven, Dept Microbiol Immunol & Transplantat, Lab Clin Microbiol, Leuven, Belgium

[11] Katholieke Univ Leuven, Dept Microbiol Immunol & Transplantat, Lab Clin & Epidemiol Virol, Leuven, Belgium

[12] CHR Orleans, Serv Malad Infect, Orleans, France

来源：

CELL REPORTS MEDICINE | 2022年 / 3卷 / 12期

关键词：

EFFECTOR FUNCTIONS; SUBVARIANTS;

D O I：

10.1016/j.xcrm.2022.100850

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The emergence of Omicron sublineages impacts the therapeutic efficacy of anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) monoclonal antibodies (mAbs). Here, we evaluate neutralization and antibody-dependent cellular cytotoxicity (ADCC) activities of 6 therapeutic mAbs against Delta, BA.2, BA.4, and BA.5. The Omicron subvariants escape most antibodies but remain sensitive to bebtelovimab and cilgavimab. Consistent with their shared spike sequence, BA.4 and BA.5 display identical neutralization profiles. Sotrovimab is the most efficient at eliciting ADCC. We also analyze 121 sera from 40 immunocompromised individuals up to 6 months after infusion of Ronapreve (imdevimab + casirivimab) or Evusheld (cilgavimab + tixagevimab). Sera from Ronapreve-treated individuals do not neutralize Omicron subvariants. Evusheld-treated individuals neutralize BA.2 and BA.5, but titers are reduced. A longitudinal evaluation of sera from Evusheld-treated patients reveals a slow decay of mAb levels and neutralization, which is faster against BA.5. Our data shed light on antiviral activities of therapeutic mAbs and the duration of effectiveness of Evusheld pre-exposure prophylaxis.

引用

页数：14

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