Anticancer effect of curcumin on breast cancer and stem cells

被引：108

作者：

Liu, Hui-Tien ^{[1
]}

Ho, Yuan-Soon ^{[1
,2
]}

机构：

[1] Taipei Med Univ, Grad Inst Med Sci, Coll Mediine, Taipei, Taiwan

[2] Taipei Med Univ, Grad Inst Med Sci, Coll Med Sci & Technol, Taipei, Taiwan

来源：

FOOD SCIENCE AND HUMAN WELLNESS | 2018年 / 7卷 / 02期

关键词：

Curcumin; Breast cancer; Breast cancer stem cell; CATENIN SIGNALING PATHWAY; KAPPA-B; INDUCED APOPTOSIS; GENE-EXPRESSION; PROLIFERATION; INHIBITION; TELOMERASE; INDUCTION; SUPPRESSION; PRODUCTS;

D O I：

10.1016/j.fshw.2018.06.001

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Numerous studies have shown that curcumin, a natural compound, exerts anticancer effects by inhibiting cancer cell proliferation and metastasis and by inducing cell cycle arrest and apoptosis. In particular, curcumin exhibits potent inhibitory effects on breast cancer, the most prevalent type of cancer among women worldwide. It has low maximal inhibitory concentration for breast cancer cell lines that express the hormone receptor ER and sensitizes cell lines to anticancer drugs. Moreover, it can induce apoptosis in cell lines independently of hormone receptor expression. In addition, curcumin inhibits the proliferation of breast cancer stem cells (BCSC), an important factor that influences cancer recurrence. The inhibition of BCSC proliferation suppresses metastasis and reattachment, ultimately limiting tumor formation. A xenograft study similarly showed that curcumin exerts tumor-suppression effects on cancer cells and cancer stem cells. Therefore, curcumin is a potential anticancer compound, and its concurrent application with other anticancer drugs appears promising. (C) 2018 "Society information". Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

引用

页码：134 / 137

页数：4

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