Biopolymer-mediated synthesis of Fe3O4 nanoparticles and investigation of their in vitro cytotoxicity effects

被引：22

作者：

Gholoobi, Aida ^{[1
]}

Meshkat, Zahra ^{[2
]}

Abnous, Khalil ^{[3
]}

Ghayour-Mobarhan, Majid ^{[4
]}

Ramezani, Mohammad ^{[3
]}

Shandiz, Fatemeh Homaei ^{[5
]}

Verma, K. D. ^{[6
]}

Darroudi, Majid ^{[7
]}

机构：

[1] Mashhad Univ Med Sci, Dept Modern Sci & Technol, Mashhad, Iran

[2] Mashhad Univ Med Sci, Womens Hlth Res Ctr, Mashhad, Iran

[3] Mashhad Univ Med Sci, Pharmaceut Res Ctr, Mashhad, Iran

[4] Mashhad Univ Med Sci, Biochem & Nutr Res Ctr, Mashhad, Iran

[5] Mashhad Univ Med Sci, Canc Res Ctr, Mashhad, Iran

[6] SV Coll, Dept Phys, Mat Sci Res Lab, Aligarh 202001, Uttar Pradesh, India

[7] Mashhad Univ Med Sci, NMRC, Mashhad, Iran

来源：

JOURNAL OF MOLECULAR STRUCTURE | 2017年 / 1141卷

关键词：

Superparamagnetic iron oxide nanoparticles (SPIONs); Starch; Powder X-ray diffraction (PXRD); Field emission scanning electron microscopy (FESEM); In vitro cytotoxicity; IRON-OXIDE NANOPARTICLES; MAGNETITE NANOPARTICLES; CANCER-CELLS; GOLD NANOPARTICLES; POLYOL PROCESS; DRUG-DELIVERY; HYPERTHERMIA; SURFACE; SHELL; ADSORPTION;

D O I：

10.1016/j.molstruc.2017.04.024

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Superparamagnetic iron oxide nanoparticles (SPIONs; Fe3O4) were synthesized by a "green" co precipitation method in aqueous starch solution as a food media. Powder X-ray diffraction (PXRD) patterns indicated that the synthesized samples were pure Fe3O4 with a spinel structure, and the coating of starch did not undergo any phase change. Fourier transform infrared (MR) spectra confirmed the formation of starch coated Fe3O4 nanoparticles. Field emission scanning electron microscopy (FESEM) micrographs illustrated the formation of nanoparticles in the size range of below 25 nm. Magnetic measurements revealed that the saturated magnetization of the starch-SPIONs reached 36.5 emu/g. The non-toxic effect of SPIONs concentration below 50 and 100 mu g/ml was observed in the studies of in vitro cytotoxicity on normal and cancerous cell lines, respectively. The dose dependent toxicity made it a suitable candidate for various medical applications. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：594 / 599

页数：6

共 51 条

[1] Synthesis of high magnetization hydrophilic magnetite (Fe3O4) nanoparticles in single reaction-Surfactantless polyol process [J].

Abbas, Mohamed ;

Rao, B. Parvatheeswara ;

Naga, S. M. ;

Takahashi, Migaku ;

Kim, CheolGi .

CERAMICS INTERNATIONAL, 2013, 39 (07) :7605-7611

[2] Soft Template Synthesis of Super Paramagnetic Fe3O4 Nanoparticles a Novel Technique [J].

Ahmad, Sharif ;

Riaz, Ufana ;

Kaushik, Ajeet ;

Alam, Javed .

JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS, 2009, 19 (03) :355-360

[3] Synthesis and spectroscopic investigations of iron oxide nano-particles for biomedical applications in the treatment of cancer cells [J].

Atta, Aly H. ;

El-ghamry, Mosad A. ;

Hamzaoui, Adel ;

Refat, Moamen S. .

JOURNAL OF MOLECULAR STRUCTURE, 2015, 1086 :246-254

[4] Carboxyl decorated Fe3O4 nanoparticles for MRI diagnosis and localized hyperthermia [J].

Barick, K. C. ;

Singh, Sarika ;

Bahadur, D. ;

Lawande, Malini A. ;

Patkar, Deepak P. ;

Hassan, P. A. .

JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2014, 418 :120-125

[5] Preparation and characterization of YADH-bound magnetic nanoparticles [J].

Chen, DH ;

Liao, MH .

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 2002, 16 (5-6) :283-291

[6] THE SYSTEM IRON OXYGEN .2. EQUILIBRIUM AND THERMODYNAMICS OF LIQUID OXIDE AND OTHER PHASES [J].

DARKEN, LS ;

GURRY, RW .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1946, 68 (05) :798-816

[7] Nanoceria: Gum mediated synthesis and in vitro viability assay [J].

Darroudi, Majid ;

Sarani, Mina ;

Oskuee, Reza Kazemi ;

Zak, Ali Khorsand ;

Amiri, Mohammad Sadegh .

CERAMICS INTERNATIONAL, 2014, 40 (02) :2863-2868

[8] Solvothermal reactions: an original route for the synthesis of novel materials [J].

Demazeau, Gerard .

JOURNAL OF MATERIALS SCIENCE, 2008, 43 (07) :2104-2114

[9] Design and construction of polymerized-chitosan coated Fe3O4 magnetic nanoparticles and its application for hydrophobic drug delivery [J].

Ding, Yongling ;

Shen, Shirley Z. ;

Sun, Huadong ;

Sun, Kangning ;

Liu, Futian ;

Qi, Yushi ;

Yan, Jun .

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2015, 48 :487-498

[10] Preparation of Fe3O4 magnetic nanoparticles coated with gallic acid for drug delivery [J].

Dorniani, Dena ;

Bin Hussein, Mohd Zobir ;

Kura, Aminu Umar ;

Fakurazi, Sharida ;

Shaari, Abdul Halim ;

Ahmad, Zalinah .

INTERNATIONAL JOURNAL OF NANOMEDICINE, 2012, 7 :5745-5756

← 1 2 3 4 5 6 →