Electrochemical N-acylation synthesis of amides under aqueous conditions

被引：44

作者：

Ke, Fang ^{[1
]}

Xu, Yiwen ^{[1
]}

Zhu, Suning ^{[1
]}

Lin, Xiaoyan ^{[1
]}

Lin, Chen ^{[1
]}

Zhou, Sunying ^{[1
]}

Su, Huimin ^{[1
]}

机构：

[1] Fujian Med Univ, Inst Materia Med, Sch Pharm, Fujian Prov Key Lab Nat Med Pharmacol, Fuzhou 350122, Fujian, Peoples R China

来源：

GREEN CHEMISTRY | 2019年 / 21卷 / 16期

关键词：

CHEMISTRY RESEARCH AREAS; CARBOXYLIC-ACIDS; COUPLING REAGENTS; DIRECT AMIDATION; BOND FORMATION; SUBSTITUTION; PERSPECTIVE; ANTICANCER; CATALYST; CASCADE;

D O I：

10.1039/c9gc01391a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An electrochemical N-acylation of carboxylic acids with amines was reported. The sustainable TBAB electrocatalysis proceeded with excellent chemoselectivity and positional selectivity, and with ample scope, allowing electrochemical N-acylation under mild reaction conditions at room temperature in water. Moreover, the synthetic utility of the current method is demonstrated by the synthesis of melatonin.

引用

页码：4329 / 4333

页数：5

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