Beneficial effect of pharmacological mobilization of bone marrow in experimental cerebral ischemia

被引：94

作者：

Six, I ^{[1
]}

Gasan, G ^{[1
]}

Mura, E ^{[1
]}

Bordet, R ^{[1
]}

机构：

[1] Univ Lille 2, Fac Med, Pharmacol Lab, F-59045 Lille, France

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2003年 / 458卷 / 03期

关键词：

cerebral ischemia; growth factor; bone marrow;

D O I：

10.1016/S0014-2999(02)02785-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Bone marrow stem cells are able to differentiate into nervous and endothelial cells. In our study, we found that administration of a bone marrow-stimulating factor (granulocyte colony-stimulating factor; G-CSF 50 mug/kg) decrease the brain infarct volume and enhance survival rate in a model of cerebral ischemia. Taken together, these data suggest a beneficial effect of a pharmacological endogenous bone marrow mobilization in the course of cerebral ischemia and open a new direction for cellular therapy strategy in stroke. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：327 / 328

页数：2

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