Expression of extracellular matrix proteins in ameloblastomas and adenomatoid odontogenic tumors

被引:14
作者
Costa de Medeiros, Ana Miryam [2 ]
Weege Nonaka, Cassiano Francisco [2 ]
Galvao, Hebel Cavalcanti [2 ]
de Souza, Lelia Batista [2 ]
Freitas, Roseana de Almeida [1 ,2 ]
机构
[1] Univ Fed Rio Grande do Norte, Programa Posgrad Patol Oral, Dept Odontol, BR-59056000 Natal, RN, Brazil
[2] Univ Fed Rio Grande do Norte, Dept Oral Pathol, Sch Dent, BR-59056000 Natal, RN, Brazil
关键词
Ameloblastoma; Adenomatoid odontogenic tumor; Fibronectin; Tenascin; Collagen; DESMOPLASTIC AMELOBLASTOMA; LOCAL INVASIVENESS; TOOTH GERMS; TENASCIN-C; FIBRONECTIN; COMPONENTS; IMMUNOEXPRESSION; LOCALIZATION; INTEGRINS; MOLECULES;
D O I
10.1007/s00405-009-0996-6
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
This study evaluated the expression of fibronectin, tenascin and type I collagen in ameloblastomas and adenomatoid odontogenic tumors (AOTs) aiming to contribute with the comprehension of the differences in the biological behavior of these tumors. Immunohistochemical technique was performed in 20 cases of ameloblastoma (16 solid and 4 desmoplastic) and in 10 cases of AOT. All tumors presented moderate fibronectin expression in the stroma. Solid ameloblastomas showed intense expression of fibronectin at the epithelial-mesenchymal interface, whereas desmoplastic ameloblastomas revealed no immunoexpression of fibronectin at this site. Ameloblastomas presented stronger immunoreactivity to tenascin than AOTs, especially at the epithelial-mesenchymal interface. AOTs and desmoplastic ameloblastomas showed intense labeling for type I collagen. The patterns of expression of the proteins studied agree with the locally more invasive behavior of ameloblastomas in comparison to AOTs. Our results might suggest a less invasive behavior of desmoplastic ameloblastoma in comparison to solid ameloblastoma.
引用
收藏
页码:303 / 310
页数:8
相关论文
共 36 条
[1]   Immunolocalization of cell signaling molecules in the granular cell ameloblastoma [J].
Ara, Sathi Gul San ;
Han, Phuu Pwint ;
Tamamura, Ryo ;
Nagatsuka, Hitoshi ;
Hu, Hailong ;
Katase, Naoki ;
Nagai, Noriyuki .
JOURNAL OF ORAL PATHOLOGY & MEDICINE, 2007, 36 (10) :609-614
[2]   Intercellular invasion and the organizational stability of tissues: a role for fibronectin [J].
Armstrong, PB ;
Armstrong, MT .
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2000, 1470 (02) :O9-O20
[3]   Matrix metalloprotease inhibitors: design from structure [J].
Borkakoti, N .
BIOCHEMICAL SOCIETY TRANSACTIONS, 2004, 32 :17-20
[4]   Tenascins [J].
Chiquet-Ehrismann, R .
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2004, 36 (06) :986-990
[5]   Extracellular matrix expression and periodontal wound-healing dynamics following guided tissue regeneration therapy in canine furcation defects [J].
Christgau, Michael ;
Caffesse, Raul G. ;
Schmalz, Gottfried ;
D'Souza, Rena N. .
JOURNAL OF CLINICAL PERIODONTOLOGY, 2007, 34 (08) :691-708
[6]   Tenascin and fibronectin expression in odontogenic cysts [J].
de Oliveira, MDC ;
de Miranda, JL ;
de Amorim, RFB ;
de Souza, LB ;
Freitas, RD .
JOURNAL OF ORAL PATHOLOGY & MEDICINE, 2004, 33 (06) :354-359
[7]   Immunoexpression of integrins in ameloblastoma, adenomatoid odontogenic tumor, and human tooth germs [J].
de Souza Andrade, Emanuel Savio ;
da Costa Miguel, Marcia Cristina ;
Freitas, Roseana de Almeida ;
Pinto, Leao Pereira ;
de Souza, Lelia Batista .
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY, 2008, 16 (03) :277-285
[8]  
DELZANGLES G, 1997, J ENDODONT, V23, P965, DOI DOI 10.1016/S0099-2399(06)81122-2
[9]  
Santos Jean Nunes dos, 2006, Rev. Bras. Otorrinolaringol., V72, P709, DOI 10.1590/S0034-72992006000500020
[10]   AMELOBLASTOMAS WITH PRONOUNCED DESMOPLASIA [J].
EVERSOLE, LR ;
LEIDER, AS ;
HANSEN, LS .
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 1984, 42 (11) :735-740