Analysis of designer drugs in human blood using gas chromatography mass spectrometry

被引：0

作者：

Chen, Xueguo ^{[1
]}

Zhao, Dan ^{[1
]}

机构：

[1] Natl Police Univ China, Dept Forens Chem, Shenyang, Liaoning, Peoples R China

来源：

PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2017年 / 30卷 / 03期

关键词：

Gas chromatography-mass spectrometry; designer drug; synthetic cathinones; human blood; BATH SALTS; GC-MS; URINE; ABUSE;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A robust gas chromatography-mass spectrometry method was utilized in the qualitative and quantitative analysis of designer drugs in human blood. Designer drugs, including methcathinone, 3, 4-methylenedioxymethcathinone, 4'-methyl-alpha-pyrrolidinopropiophenone and methylenedioxy-pyrovalerone were simultaneously analyzed by gas chromatography-mass spectrometry. Liquid-liquid small volume extraction, was employed in the pretreatment of human blood sample, and the experimental results showed that the method was validated with high extraction efficiency, low limits of detection and good linearity throughout the studied concentration ranges. Furthermore, the method not only exhibited good accuracy and precision in the determination of designer drugs in human blood, but also showed the potential of the approach in the determination of trace evidence in forensic science.

引用

页码：903 / 906

页数：4

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