A series of water-soluble fluorescent probe for viscosity detection and their biological application

被引：4

作者：

Wang, Hui ^{[1
]}

Cai, Fengze ^{[1
]}

Zhou, Le ^{[1
]}

Li, Di ^{[1
]}

Feng, Dexiang ^{[1
]}

Wei, Yan ^{[1
]}

Feng, Zhijun ^{[1
]}

Gu, Xiaoxia ^{[1
]}

Li, Xiangzi ^{[1
]}

Wu, Yunjun ^{[1
]}

机构：

[1] Wannan Med Coll, Dept Chem, Anhui Prov Engn Res Ctr Polysaccharide Drugs, Wuhu 241002, Peoples R China

来源：

POLYHEDRON | 2019年 / 170卷

基金：

中国国家自然科学基金;

关键词：

Quinoline derivatives; Viscosity; Water-soluble; Fluorescence probe; Bioimaging; LIVING CELLS; OPTICAL-PROPERTIES; MEMBRANE; EMISSION; BIOSENSORS; SENSOR;

D O I：

10.1016/j.poly.2019.06.015

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A series of novel quinoline derivatives L1-L3 with a D-pi-A type were developed as a fluorescent viscosity probe in vitro. L1-L3 displayed very weak emission in nonviscous media and remarkable fluorescence enhancement with the viscosity augment in the water/glycerol system, especially for 12. Different substituent units exhibit a considerable influence on the photophysical properties and response sensitivity of the probes to viscosity. Probes L1-L3 exhibited a direct linear relationship well between log (I/I-0) and the log eta, which allowed us to quantitatively measure the environmental viscosity. Moreover, L2 modified with 1-butoxy-2-methoxybenzene has been certified to be more sensitive to viscosity because of moderate electron-donating ability. Cell imaging experiments illustrated that L1-L3 is suitable for visualizing the viscosity changes in living cells. As a result, the present work offers a strategy for rationally designing fluorescence probe for viscosity detection in living cells. (C) 2019 Elsevier Ltd. All rights reserved.

引用

页码：440 / 446

页数：7

共 31 条

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