Fate Mapping via Ms4a3-Expression History Traces Monocyte-Derived Cells

被引：389
作者：
Liu, Zhaoyuan [1 ]
Gu, Yaqi [1 ]
Chakarov, Svetoslav [2 ]
Bleriot, Camille [2 ]
Kwok, Immanuel [2 ]
Chen, Xin [1 ]
Shin, Amanda [1 ]
Huang, Weijie [1 ]
Dress, Regine J. [2 ]
Dutertre, Charles-Antoine [2 ]
Schlitzer, Andreas [3 ]
Chen, Jinmiao [2 ]
Ng, Lai Guan [2 ]
Wang, Honglin [1 ]
Liu, Zhiduo [1 ]
Su, Bing [1 ,4 ]
Ginhoux, Florent [1 ,2 ,5 ]
机构：
[1] Shanghai Jiao Tong Univ, Shanghai Inst Immunol, Dept Immunol & Microbiol, Sch Med, Shanghai 200025, Peoples R China
[2] Agcy Sci Technol & Res, Singapore Immunol Network, Singapore 138648, Singapore
[3] Univ Bonn, LIMES Inst, Myeloid Cell Biol, D-53115 Bonn, Germany
[4] Shanghai Jiao Tong Univ, Key Lab Cell Differentiat & Apoptosis, Chinese Minist Educ, Sch Med, Shanghai 200025, Peoples R China
[5] SingHlth Duke NUS Acad Med Ctr, Translat Immunol Inst, Singapore, Singapore
来源：
CELL | 2019年 / 178卷 / 06期
基金：
新加坡国家研究基金会; 中国国家自然科学基金;
关键词：
PLASMACYTOID DENDRITIC CELLS; GENE-EXPRESSION; MACROPHAGES; TISSUE; PROGENITORS; REVEALS; LINEAGE; HETEROGENEITY; PRECURSORS; CX(3)CR1;
D O I：
10.1016/j.cell.2019.08.009
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Most tissue-resident macrophage (RTM) populations are seeded by waves of embryonic hematopoiesis and are self-maintained independently of a bone marrow contribution during adulthood. A proportion of RTMs, however, is constantly replaced by blood monocytes, and their functions compared to embryonic RTMs remain unclear. The kinetics and extent of the contribution of circulating monocytes to RTM replacement during homeostasis, inflammation, and disease are highly debated. Here, we identified Ms4a3 as a specific gene expressed by granulocyte-monocyte progenitors (GMPs) and subsequently generated Ms4a3(TdT) reporter, Ms4a3(Cre), and Ms4a3(CreERT2) fate-mapping models. These models traced efficiently monocytes and granulocytes, but no lymphocytes or tissue dendritic cells. Using these models, we precisely quantified the contribution of monocytes to the RTM pool during homeostasis and inflammation. The unambiguous idenification of monocyte-derived cells will permit future studies of their function under any condition.
引用
收藏
页码：1509 / +
页数：36
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