A Functional Genomics Approach to Tanshinone Biosynthesis Provides Stereochemical Insights

被引：221
|
作者：
Gao, Wei [1 ,2 ]
Hillwig, Matthew L. [3 ]
Huang, Luqi [1 ]
Cui, Guanghong [1 ]
Wang, Xueyong [1 ]
Kong, Jianqiang [4 ]
Yang, Bin [1 ]
Peters, Reuben J. [3 ]
机构：
[1] Chinese Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China
[2] Capital Med Univ, Sch Tradit Chinese Med, Beijing 100069, Peoples R China
[3] Iowa State Univ, Dept Biochem Biophys & Mol Biol, Ames, IA 50011 USA
[4] Peking Union Med Coll, Beijing 100050, Peoples R China
来源：
ORGANIC LETTERS | 2009年 / 11卷 / 22期
关键词：
ABIETADIENE SYNTHASE; (+)-COPALYL DIPHOSPHATE; ABIES-GRANDIS; MECHANISM; PLANTS;
D O I：
10.1021/ol902051v
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Tanshinones are abietane-type norditerpenoid quinone natural products that are the bioactive components of the Chinese medicinal herb Salvia miltiorrhiza Bunge. The initial results from a functional genomics-based investigation of tanshinone biosynthesis, specifically the functional identification of the relevant diterpene synthases from S. miltiorrhiza, are reported, The cyclohexa-1,4-diene arrangement of the distal ring poises the resulting miltiradiene for the ensuing aromatization and hydroxylation to ferruginol suggested for tanshinone biosynthesis.
引用
收藏
页码：5170 / 5173
页数：4
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