共 30 条
Diabetic Ketoacidosis and Memory Dysfunction in Children with Type 1 Diabetes
被引:98
作者:
Ghetti, Simona
[1
,2
]
Lee, Joshua K.
[1
,2
]
Sims, Clare E.
[3
]
DeMaster, Dana M.
[1
,2
]
Glaser, Nicole S.
[4
]
机构:
[1] Univ Calif Davis, Dept Psychol, Davis, CA 95616 USA
[2] Univ Calif Davis, Ctr Mind & Brain, Davis, CA 95616 USA
[3] Univ Colorado, Dept Psychol, Boulder, CO 80309 USA
[4] Univ Calif Davis, Sch Med, Dept Pediat, Div Endocrinol, Davis, CA 95616 USA
关键词:
CEREBRAL EDEMA;
SEVERE HYPOGLYCEMIA;
SPATIAL MEMORY;
TEMPORAL-LOBE;
RECOLLECTION;
RATS;
FAMILIARITY;
FREQUENCY;
MELLITUS;
HYPOXIA;
D O I:
10.1016/j.jpeds.2009.07.054
中图分类号:
R72 [儿科学];
学科分类号:
100202 ;
摘要:
Objective We tested the hypothesis that diabetic ketoacidosis (DKA) results in memory deficits typical of hypoxic/ischemic injury because recent studies suggest that cerebral metabolic changes similar to those observed in hypoxic/ischemic cerebral injury are observed in children with DKA, even without symptoms suggesting cerebral injury. Study design Thirty-three children with type 1 diabetes mellitus (T1DM) and a history of DKA and 29 children with T1DM without a history of DKA were enrolled from an academic hospital pediatric endocrinology clinic. These groups were comparable on demographic and disease-related variables. These groups' ability to recall events in association with specific details, the memory function most directly affected by mild hypoxia/ischemia, was compared on 2 tasks (ie, event-color associations and event-spatial position associations). Results In multivariate analyses controlling for other critical variables, children with DKA history had significantly lower rates of accurate memory on both tasks (mean, 0.34 +/- 0.13 on the color task and 0.57 +/- 0.15 on the spatial task) than did children without DKA history (mean, 0.44 +/- 0.11 and 0.65 +/- 0.18, P < .01). Conclusions DKA disrupts memory function, underscoring the importance of DKA prevention when T1DM is known and prompt diagnosis of children with new onset of T1DM. (J Pediatr 2010; 156: 109-14).
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页码:109 / 114
页数:6
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