Diabetic Ketoacidosis and Memory Dysfunction in Children with Type 1 Diabetes

被引:98
作者
Ghetti, Simona [1 ,2 ]
Lee, Joshua K. [1 ,2 ]
Sims, Clare E. [3 ]
DeMaster, Dana M. [1 ,2 ]
Glaser, Nicole S. [4 ]
机构
[1] Univ Calif Davis, Dept Psychol, Davis, CA 95616 USA
[2] Univ Calif Davis, Ctr Mind & Brain, Davis, CA 95616 USA
[3] Univ Colorado, Dept Psychol, Boulder, CO 80309 USA
[4] Univ Calif Davis, Sch Med, Dept Pediat, Div Endocrinol, Davis, CA 95616 USA
关键词
CEREBRAL EDEMA; SEVERE HYPOGLYCEMIA; SPATIAL MEMORY; TEMPORAL-LOBE; RECOLLECTION; RATS; FAMILIARITY; FREQUENCY; MELLITUS; HYPOXIA;
D O I
10.1016/j.jpeds.2009.07.054
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Objective We tested the hypothesis that diabetic ketoacidosis (DKA) results in memory deficits typical of hypoxic/ischemic injury because recent studies suggest that cerebral metabolic changes similar to those observed in hypoxic/ischemic cerebral injury are observed in children with DKA, even without symptoms suggesting cerebral injury. Study design Thirty-three children with type 1 diabetes mellitus (T1DM) and a history of DKA and 29 children with T1DM without a history of DKA were enrolled from an academic hospital pediatric endocrinology clinic. These groups were comparable on demographic and disease-related variables. These groups' ability to recall events in association with specific details, the memory function most directly affected by mild hypoxia/ischemia, was compared on 2 tasks (ie, event-color associations and event-spatial position associations). Results In multivariate analyses controlling for other critical variables, children with DKA history had significantly lower rates of accurate memory on both tasks (mean, 0.34 +/- 0.13 on the color task and 0.57 +/- 0.15 on the spatial task) than did children without DKA history (mean, 0.44 +/- 0.11 and 0.65 +/- 0.18, P < .01). Conclusions DKA disrupts memory function, underscoring the importance of DKA prevention when T1DM is known and prompt diagnosis of children with new onset of T1DM. (J Pediatr 2010; 156: 109-14).
引用
收藏
页码:109 / 114
页数:6
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