Cyclonet - An integrated database on cell cycle regulation and carcinogenesis

Motivation: Success of the biologically reasonable modeling of cellular systems depends on the completeness of our knowledge and integration of all fundamental molecular processes, such as signal transduction, regulation of gene expression and metabolism. Mammalian cell cycle is a good example of the system where such natural integration of all the molecular processes plays important role in their regulation. Despite of the massive development of various biological databases, no specialized repository was created so far that would integrate all knowledge on cell cycle. Results: We have developed the Cyclonet - an integrated database on cell cycle regulation and carcinogenesis. It contains information about known specific genes, proteins and their complexes involved in regulation of cell cycle and carcinogenesis; diagrams of cell cycle regulation and related processes; models of cell cycle and results of their simulation; links on microarray data on cell cycle and on various types of cancer, information on anticancer drug targets as well as their ligands, broad literature references and other related resources.