Positive HCMV DNAemia in stem cell recipients undergoing letermovir prophylaxis is expression of abortive infection

被引：55

作者：

Cassaniti, Irene ^{[1
]}

Colombo, Anna A. ^{[2
]}

Bernasconi, Paolo ^{[2
]}

Malagola, Michele ^{[3
]}

Russo, Domenico ^{[3
]}

Iori, Anna P. ^{[4
]}

Girmenia, Corrado ^{[4
]}

Greco, Raffaella ^{[5
]}

Peccatori, Jacopo ^{[5
]}

Ciceri, Fabio ^{[5
]}

Bonifazi, Francesca ^{[6
]}

Percivalle, Elena ^{[1
]}

Campanini, Giulia ^{[1
]}

Piccirilli, Giulia ^{[7
]}

Lazzarotto, Tiziana ^{[7
]}

Baldanti, Fausto ^{[1
,8
]}

机构：

[1] Fdn IRCCS Policlin San Matteo, Microbiol & Virol Dept, Mol Virol Unit, Pavia, Italy

[2] Fdn IRCCS Policlin San Matteo, Div Haematol, Hemopoiet Stem Cell Unit, Pavia, Italy

[3] Univ Brescia, Spedali Civili Brescia, Dept Clin & Expt Sci, Unit Blood Dis & Stem Cell Transplantat, Brescia, Italy

[4] Sapienza Univ, Azienda Policlin Umberto I, Dept Haematol Oncol & Dermatol, Rome, Italy

[5] IRCCS San Raffaele Sci Inst, Haematol & Bone Marrow Transplant Unit, Milan, Italy

[6] IRCCS Azienda Osped Univ Bologna, Dept Expt Diagnost & Specialty Med, Bologna, Italy

[7] Univ Bologna, St Orsola Polyclin, Operat Unit Clin Microbiol, Dept Specialized Expt & Diagnost Med, Bologna, Italy

[8] Univ Pavia, Dept Clin Surg Diagnost & Pediat Sci, Pavia, Italy

来源：

AMERICAN JOURNAL OF TRANSPLANTATION | 2021年 / 21卷 / 04期

关键词：

clinical research/practice; infection and infectious agents - viral: Cytomegalovirus (CMV); infectious disease; molecular biology; molecular biology: DNA; translational research/science;

D O I：

10.1111/ajt.16450

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Letermovir (LMV) inhibits HCMV replication by binding to components of the HCMV-terminase complex showing a potential role in prevention of HCMV-related complications in allogenic hematopoietic stem cell transplant recipients (allo-HSCTRs). However, little is known about breakthrough HCMV infection and the relevance of HCMV DNAemia during prophylaxis. We reported the results of a multicenter prospective study involving five Italian centers in the management of HCMV DNAemia in 75 adult HCMV-seropositive allo-HSCTRs undergoing LMV prophylaxis. The aim of the present study was to characterize the presence of real HCMV reactivation during LMV prophylaxis. Then, the presence of circulating infectious HCMV particles was determined by virus isolation and degradation of free-floating viral DNA. This report provides the first evidence that during LMV prophylaxis the clinical relevance of HCMV DNAemia should be critically considered.

引用

页码：1622 / 1628

页数：7

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