Correlates of protection against SARS-CoV-2 in rhesus macaques

被引：805

作者：

McMahan, Katherine ^{[1
]}

Yu, Jingyou ^{[1
]}

Mercado, Noe B. ^{[1
]}

Loos, Carolin ^{[2
,3
]}

Tostanoski, Lisa H. ^{[1
]}

Chandrashekar, Abishek ^{[1
]}

Liu, Jinyan ^{[1
]}

Peter, Lauren ^{[1
]}

Atyeo, Caroline ^{[2
,4
]}

Zhu, Alex ^{[2
]}

Bondzie, Esther A. ^{[1
]}

Dagotto, Gabriel ^{[1
,4
]}

Gebre, Makda S. ^{[1
,4
]}

Jacob-Dolan, Catherine ^{[1
,4
]}

Li, Zhenfeng ^{[1
]}

Nampanya, Felix ^{[1
]}

Patel, Shivani ^{[1
]}

Pessaint, Laurent ^{[5
]}

Van Ry, Alex ^{[5
]}

Blade, Kelvin ^{[5
]}

Yalley-Ogunro, Jake ^{[5
]}

Cabus, Mehtap ^{[5
]}

Brown, Renita ^{[5
]}

Cook, Anthony ^{[5
]}

Teow, Elyse ^{[5
]}

Andersen, Hanne ^{[5
]}

Lewis, Mark G. ^{[5
]}

Lauffenburger, Douglas A. ^{[3
]}

Alter, Galit ^{[2
,6
]}

Barouch, Dan H. ^{[1
,2
,4
,6
]}

机构：

[1] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Ctr Virol & Vaccine Res, Boston, MA 02115 USA

[2] Ragon Inst MGH MIT & Harvard, Cambridge, MA 02139 USA

[3] MIT, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[4] Harvard Med Sch, Boston, MA 02115 USA

[5] Bioqual, Rockville, MD USA

[6] Massachusetts Consortium Pathogen Readiness, Boston, MA USA

来源：

NATURE | 2021年 / 590卷 / 7847期

基金：

比尔及梅琳达.盖茨基金会; 美国国家卫生研究院;

关键词：

IMMUNITY;

D O I：

10.1038/s41586-020-03041-6

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Adoptive transfer of purified IgG from convalescent macaques protects naive macaques against SARS-CoV-2 infection, and cellular immune responses contribute to protection against rechallenge with SARS-CoV-2. Recent studies have reported the protective efficacy of both natural(1) and vaccine-induced(2-7) immunity against challenge with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in rhesus macaques. However, the importance of humoral and cellular immunity for protection against infection with SARS-CoV-2 remains to be determined. Here we show that the adoptive transfer of purified IgG from convalescent rhesus macaques (Macaca mulatta) protects naive recipient macaques against challenge with SARS-CoV-2 in a dose-dependent fashion. Depletion of CD8(+) T cells in convalescent macaques partially abrogated the protective efficacy of natural immunity against rechallenge with SARS-CoV-2, which suggests a role for cellular immunity in the context of waning or subprotective antibody titres. These data demonstrate that relatively low antibody titres are sufficient for protection against SARS-CoV-2 in rhesus macaques, and that cellular immune responses may contribute to protection if antibody responses are suboptimal. We also show that higher antibody titres are required for treatment of SARS-CoV-2 infection in macaques. These findings have implications for the development of SARS-CoV-2 vaccines and immune-based therapeutic agents.

引用

页码：630 / 634

页数：20

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