Recent Trends in Chiral Separations by 2D-HPLC

被引：11

作者：

Ali, Imran ^{[1
,2
]}

Suhail, Mohd. ^{[2
]}

Aboul-Enein, Hassan Y. ^{[3
]}

Kon'kova, Tatiana ^{[4
]}

机构：

[1] Taibah Univ, Dept Chem, POB 30002, Al Madinah Al Munawarah 14177, Saudi Arabia

[2] Jamia Millia Islamia, Dept Chem, New Delhi 11025, India

[3] Natl Res Ctr, Pharmaceut & Drug Ind Res Div, Pharmaceut & Med Chem Dept, Cairo 12311, Egypt

[4] Mendeleev Univ Chem Technol, Dept Inorgan Subst Technol & Electrochem Proc, 9 Miusskaya Sq, Moscow 125047, Russia

来源：

CHROMATOGRAPHIA | 2021年 / 84卷 / 06期

关键词：

2D-HPLC; Chiral separations; Applications; Challenges and future perspectives; LIQUID-CHROMATOGRAPHY; MASS-SPECTROMETRY;

D O I：

10.1007/s10337-021-04030-1

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

2D-HPLC is an important development in chiral separations due to its excellent capability to resolve the enantiomers. This article describes the latest update in the chiral resolution of racemates using 2D-HPLC. The various aspects of the chiral resolution such as validation, optimization, and applications are discussed in both biological and environmental matrices. Some latest developments of nano-2D-HPLC are also included. Besides, efforts are made to discuss the challenges and future perspectives. During the preparation of this article, it was observed that much work has not been done in this direction and only a few papers describe the application of 2D-HPLC in the chiral separation. There is an urgent need to develop more 2D-HPLC methods for a variety of racemates. This article will be useful to the investigators, academicians and industry persons in the future to improve 2D-HPLC for the chiral resolution of the various racemates.

引用

页码：535 / 548

页数：14

共 81 条

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