Drug transporters and renal drug disposition in the newborn

被引:14
作者
De Gregori, Simona [1 ]
De Gregori, Manuela [2 ]
Ranzani, Guglielmina Nadia [2 ]
Borghesi, Alessandro [3 ]
Regazzi, Mario [1 ]
Stronati, Mauro [3 ]
机构
[1] Fdn IRCCS Policlin San Matteo, Clin Pharmacokinet Unit, Pavia, Italy
[2] Univ Pavia, Dept Genet & Microbiol, I-27100 Pavia, Italy
[3] Fdn IRCCS Policlin San Matteo, Neonatal Condit & Intens Care Unit, Pavia, Italy
关键词
Kidneys; transporters; genetic polymorphisms; newborns; ORGANIC ANION TRANSPORTER; SINGLE-NUCLEOTIDE POLYMORPHISMS; POSTNATAL-DEVELOPMENT; MULTIDRUG-RESISTANCE; GENE; EXPRESSION; PHARMACOKINETICS; POISONINGS; ONTOGENY; FAMILY;
D O I
10.1080/14767050903184470
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
The individual response to a drug in terms of drug efficacy and toxicity is highly variable; this represents a major problem in clinical practice. Potential causes for such variability include pathogenesis and severity of the disease being treated, drug interactions, patient age, nutritional status, renal and liver function and concomitant illness. Inherited differences in drug metabolism and genetic polymorphism of targets of drug therapy can have even greater influence on the efficacy and toxicity of medications. We will discuss the role of drug transporters (organic anion transporting polypeptides and Pgp), drug-related gene polymorphisms and pathologies, renal function and drug metabolism in a very special patient population, the newborn. Reliable predictions of drug pharmacokinetics in the newborn, derived from an understanding of the transport mechanisms, should allow therapeutic agents to be used more safely in this special population.
引用
收藏
页码:31 / 37
页数:7
相关论文
共 40 条
[31]   The organic anion transporter family: from physiology to ontogeny and the clinic [J].
Sweet, DH ;
Bush, KT ;
Nigam, SK .
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2001, 281 (02) :F197-F205
[32]   Localization of an organic anion transporter-GFP fusion construct (rROAT1-GFP) in intact proximal tubules [J].
Sweet, DH ;
Miller, DS ;
Pritchard, JB .
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 1999, 276 (06) :F864-F873
[33]   Organic anion transporter 3 (Slc22a8) is a dicarboxylate exchanger indirectly coupled to the Na+ gradient [J].
Sweet, DH ;
Chan, LMS ;
Walden, R ;
Yang, XP ;
Miller, DS ;
Pritchard, JB .
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2003, 284 (04) :F763-F769
[34]   Expression closing and characterization of ROAT1 - The basolateral organic anion transporter in rat kidney [J].
Sweet, DH ;
Wolff, NA ;
Pritchard, JB .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (48) :30088-30095
[35]  
TOSHIHISA I, 2004, BIOL PHARM BULL, V27, P939
[36]   EXPRESSION OF A FULL-LENGTH CDNA FOR THE HUMAN MDR1 GENE CONFERS RESISTANCE TO COLCHICINE, DOXORUBICIN, AND VINBLASTINE [J].
UEDA, K ;
CARDARELLI, C ;
GOTTESMAN, MM ;
PASTAN, I .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (09) :3004-3008
[37]   RENAL-FUNCTION IN VERY-LOW-BIRTH-WEIGHT INFANTS - NORMAL MATURITY REACHED DURING EARLY-CHILDHOOD [J].
VANPEE, M ;
BLENNOW, M ;
LINNE, T ;
HERIN, P ;
APERIA, A .
JOURNAL OF PEDIATRICS, 1992, 121 (05) :784-788
[38]   Drug disposition in the late preterm ("near-term") newborn [J].
Ward, RM .
SEMINARS IN PERINATOLOGY, 2006, 30 (01) :48-51
[39]  
Yaffe S.J., 2005, NEONATAL PEDIAT PHAR, P20
[40]   Polymorphism of human cytochrome P450 enzymes and its clinical impact [J].
Zhou, Shu-Feng ;
Liu, Jun-Ping ;
Chowbay, Balram .
DRUG METABOLISM REVIEWS, 2009, 41 (02) :89-295