Prognostic Factors After Surgical Treatment of Liver Metastases from Breast Cancer-19 Years of Experience

被引：2
作者：
Prochazkova, Kristyna [1 ,2 ]
Pivovarcikova, Kristyna [2 ,3 ]
Rousarova, Milena [4 ]
Vodicka, Josef [1 ,2 ]
Hosek, Petr [5 ]
Treskova, Inka [2 ,6 ]
Hes, Ondrej [2 ,3 ]
Kucera, Radek [2 ,7 ]
Topolcan, Ondrej [2 ,6 ]
Treska, Vladislav [1 ,2 ]
机构：
[1] Charles Univ Prague, Dept Surg, Fac Med Pilsen, Plzen, Czech Republic
[2] Univ Hosp, Plzen, Czech Republic
[3] Charles Univ Prague, Fac Med Pilsen, Dept Pathol, Plzen, Czech Republic
[4] Czech Natl Oncol Register, Plzen, Czech Republic
[5] Charles Univ Prague, Fac Med Pilsen, Biomed Ctr, Plzen, Czech Republic
[6] Charles Univ Prague, Fac Med Pilsen, Dept Plast Surg, Plzen, Czech Republic
[7] Charles Univ Prague, Dept Immunochem Diagnost, Fac Med Pilsen, Plzen, Czech Republic
来源：
IN VIVO | 2021年 / 35卷 / 01期
关键词：
Breast cancer; liver metastases; biomarkers; hormone receptor status; liver resection; prognostic markers; ESTROGEN-RECEPTOR; HEPATIC RESECTION; SURVIVAL; SURGERY;
D O I：
10.21873/invivo.12273
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Background/Aim: The aim of this study was to determine the importance of surgical treatment, utility of hormone receptor status and selected biomarkers in the prognosis of patients with liver metastases from breast cancer (BCLM). Patients and Methods: Thirty female underwent surgery for BCLM between 1/2000 and 1/2019. Results: The type of surgery (resection/radiofrequency ablation) had no impact on overall survival (OS) (p=0.894). Having more than one BCLM (p=0.003), expression of human epidermal receptor 2 in metastases (p=0.034), as well as an elevated presurgical level of carbohydrate antigen 19-9 (p=0.017) and postsurgical thymidine kinase (p=0.034) were negative prognostics factor for recurrence-free survival. The factors affecting OS included the number of liver procedures (p=0.021), the degree of proliferative activity (p=0.008) and elevated postsurgical carcinoembryonic antigen level (p=0.038). Conclusion: The type of surgery had no impact on OS.
引用
收藏
页码：417 / 422
页数：6
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