Determination of pKa values of tenoxicam from 1H NMR chemical shifts and of oxicams from electrophoretic mobilities (CZE) with the aid of programs SQUAD and HYPNMR

被引：36

作者：

Rodriguez-Barrientos, Damaris ^{[1
]}

Rojas-Hernandez, Alberto ^{[1
,2
]}

Gutierrez, Atilano ^{[1
]}

Moya-Hernandez, Rosario ^{[2
]}

Gomez-Balderas, Rodolfo ^{[2
]}

Teresa Ramirez-Silva, Maria ^{[1
]}

机构：

[1] Univ Autonoma Metropolitana Iztapalapa, Dept Quim, Area Quim Analit, Mexico City 09340, DF, Mexico

[2] Univ Nacl Autonoma Mexico, Fac Estudios Super Cuautitlan, Unidad Invest Multidisciplinaria, Lab Fis Quim Analit, Cuautitlan 54714, Edo de Mexico, Mexico

来源：

TALANTA | 2009年 / 80卷 / 02期

关键词：

Oxicams; SQUAD; HYPERQUAD; HYPNMR; pK(a) values; H-1 NMR chemical shifts; CZE; Electrophoretic mobility; CAPILLARY-ELECTROPHORESIS; ELECTRICAL CONDUCTANCE; IONIZATION-CONSTANTS; ACIDITY CONSTANTS; AQUEOUS-SOLUTIONS; METHANOL/WATER; QUINOLONES; MELOXICAM; DRUGS; PH;

D O I：

10.1016/j.talanta.2009.07.058

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

In this work it is explained, by the first time, the application of programs SQUAD and HYPNMR to refine equilibrium constant values through the fit of electrophoretic mobilities determined by capillary zone electrophoresis experiments, due to the mathematical isomorphism of UV-vis absorptivity coefficients, NMR chemical shifts and electrophoretic mobilities as a function of pH. Then, the pK(a) values of tenoxicam in H2O/DMSO 1:4 (v/v) have been obtained from H-1 NMR chemical shifts, as well as of oxicams in aqueous solution from electrophoretic mobilities determined by CZE, at 25 degrees C. These values are in very good agreement with those reported by spectro photometric and potentiometric measurements. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：754 / 762

页数：9

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