AGA Clinical Practice Update on Lifestyle Modification Using Diet and Exercise to Achieve Weight Loss in the Management of Nonalcoholic Fatty Liver Disease: Expert Review

被引：339

作者：

Younossi, Zobair M. ^{[1
,2
,3
]}

Corey, Kathleen E. ^{[4
]}

Lim, Joseph K. ^{[5
,6
]}

机构：

[1] Inova Fairfax Med Campus, Ctr Liver Dis, Falls Church, VA USA

[2] Inova Fairfax Med Campus, Dept Med, Falls Church, VA USA

[3] Inova Hlth Syst, Betty & Guy Beatty Ctr Integrated Res, Falls Church, VA USA

[4] Massachusetts Gen Hosp, Dept Med, Liver Ctr Div Gastroenterol, Boston, MA 02114 USA

[5] Yale Univ, Sch Med, Yale Liver Ctr, New Haven, CT USA

[6] Yale Univ, Sch Med, Sect Digest Dis, New Haven, CT USA

来源：

GASTROENTEROLOGY | 2021年 / 160卷 / 03期

关键词：

Fatty Liver; Steatohepatitis; NASH; Weight Loss; Exercise; Diet; Liver Fibrosis; Obesity; Cirrhosis; MEDITERRANEAN DIET; METABOLIC SYNDROME; FRUCTOSE CONSUMPTION; PHYSICAL-ACTIVITY; RISK; MORTALITY; OBESITY; INTERVENTION; IMPROVEMENTS; PREVALENCE;

D O I：

10.1053/j.gastro.2020.11.051

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Nonalcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease, with global public health impact affecting more than 25% of the global population. NAFLD is associated with significant morbidity and mortality from cirrhosis, hepatocellular carcinoma, solid organ malignancies, diabetes mellitus, cardiovascular disease, and obstructive sleep apnea, resulting in significant health care resource use and decreased health-related quality of life. NAFLD cirrhosis is a leading indication for liver transplantation in the United States. Lifestyle modification to achieve weight loss remains a first-line intervention in patients with NAFLD. We summarize evidence-based interventions for lifestyle modification in the treatment of NAFLD and provided best practice advice statements to address key issues in clinical management.

引用

页码：912 / 918

页数：7

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