AGA Clinical Practice Update on Lifestyle Modification Using Diet and Exercise to Achieve Weight Loss in the Management of Nonalcoholic Fatty Liver Disease: Expert Review

被引：339

作者：

Younossi, Zobair M. ^{[1
,2
,3
]}

Corey, Kathleen E. ^{[4
]}

Lim, Joseph K. ^{[5
,6
]}

机构：

[1] Inova Fairfax Med Campus, Ctr Liver Dis, Falls Church, VA USA

[2] Inova Fairfax Med Campus, Dept Med, Falls Church, VA USA

[3] Inova Hlth Syst, Betty & Guy Beatty Ctr Integrated Res, Falls Church, VA USA

[4] Massachusetts Gen Hosp, Dept Med, Liver Ctr Div Gastroenterol, Boston, MA 02114 USA

[5] Yale Univ, Sch Med, Yale Liver Ctr, New Haven, CT USA

[6] Yale Univ, Sch Med, Sect Digest Dis, New Haven, CT USA

来源：

GASTROENTEROLOGY | 2021年 / 160卷 / 03期

关键词：

Fatty Liver; Steatohepatitis; NASH; Weight Loss; Exercise; Diet; Liver Fibrosis; Obesity; Cirrhosis; MEDITERRANEAN DIET; METABOLIC SYNDROME; FRUCTOSE CONSUMPTION; PHYSICAL-ACTIVITY; RISK; MORTALITY; OBESITY; INTERVENTION; IMPROVEMENTS; PREVALENCE;

D O I：

10.1053/j.gastro.2020.11.051

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Nonalcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease, with global public health impact affecting more than 25% of the global population. NAFLD is associated with significant morbidity and mortality from cirrhosis, hepatocellular carcinoma, solid organ malignancies, diabetes mellitus, cardiovascular disease, and obstructive sleep apnea, resulting in significant health care resource use and decreased health-related quality of life. NAFLD cirrhosis is a leading indication for liver transplantation in the United States. Lifestyle modification to achieve weight loss remains a first-line intervention in patients with NAFLD. We summarize evidence-based interventions for lifestyle modification in the treatment of NAFLD and provided best practice advice statements to address key issues in clinical management.

引用

页码：912 / 918

页数：7

共 50 条

[31] AGA Clinical Practice Update on the Evaluation and Management of Acute Kidney Injury in Patients With Cirrhosis: Expert Review [J].

Flamm, Steven L. ;

Wong, Florence ;

Ahn, Joseph ;

Kamath, Patrick S. .

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2022, 20 (12) :2707-2716

[32] AGA Clinical Practice Update on Functional Gastrointestinal Symptoms in Patients With Inflammatory Bowel Disease: Expert Review [J].

Colombel, Jean-Frederic ;

Shin, Andrea ;

Gibson, Peter R. .

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2019, 17 (03) :380-+

[33] Exercise without dietary changes alleviates nonalcoholic fatty liver disease without weight loss benefits [J].

Ok, Duck-Pil ;

Ko, Kangeun ;

Bae, Ju Yong .

LIPIDS IN HEALTH AND DISEASE, 2018, 17

[34] A pilot trial of body weight reduction for nonalcoholic fatty liver disease with a home-based lifestyle modification intervention delivered in collaboration with interdisciplinary medical staff [J].

Oza, Noriko ;

Eguchi, Yuichiro ;

Mizuta, Toshihiko ;

Ishibashi, Eriko ;

Kitajima, Yoichiro ;

Horie, Hiroko ;

Ushirogawa, Michiko ;

Tsuzura, Takeko ;

Nakashita, Shunya ;

Takahashi, Hirokazu ;

Kawaguchi, Yasunori ;

Oda, Yasutomo ;

Iwakiri, Ryuichi ;

Ozaki, Iwata ;

Eguchi, Takahisa ;

Ono, Naofumi ;

Fujimoto, Kazuma .

JOURNAL OF GASTROENTEROLOGY, 2009, 44 (12) :1203-1208

[35] The American lifestyle-induced obesity syndrome diet in male and female rodents recapitulates the clinical and transcriptomic features of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis [J].

Harris, Shelley E. ;

Poolman, Toryn M. ;

Arvaniti, Anastasia ;

Cox, Roger D. ;

Gathercole, Laura L. ;

Tomlinson, Jeremy W. .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2020, 319 (03) :G345-G360

[36] Association of Weight Loss Interventions With Changes in Biomarkers of Nonalcoholic Fatty Liver Disease A Systematic Review and Meta-analysis [J].

Koutoukidis, Dimitrios A. ;

Astbury, Nerys M. ;

Tudor, Kate E. ;

Morris, Elizabeth ;

Henry, John A. ;

Noreik, Michaela ;

Jebb, Susan A. ;

Aveyard, Paul .

JAMA INTERNAL MEDICINE, 2019, 179 (09) :1262-1271

[37] Effects of a low free sugar diet on the management of nonalcoholic fatty liver disease: a randomized clinical trial [J].

Khodami, Banafshe ;

Hatami, Behzad ;

Yari, Zahra ;

Alavian, Seyyed Moayyed ;

Sadeghi, Amir ;

Varkaneh, Hamed Kord ;

Santos, Heitor O. ;

Hekmatdoost, Azita .

EUROPEAN JOURNAL OF CLINICAL NUTRITION, 2022, 76 (07) :987-994

[38] AGA Clinical Practice Update on Diagnosis and Monitoring of Celiac Disease-Changing Utility of Serology and Histologic Measures: Expert Review [J].

Husby, Steffen ;

Murray, Joseph A. ;

Katzka, David A. .

GASTROENTEROLOGY, 2019, 156 (04) :885-889

[39] Practice guidelines for the diagnosis and management of nonalcoholic fatty liver disease A decalogue from the Italian Association for the Study of the Liver (AISF) Expert Committee [J].

Loria, P. ;

Adinolfi, L. E. ;

Bellentani, S. ;

Bugianesi, E. ;

Grieco, A. ;

Fargion, S. ;

Gasbarrini, A. ;

Loguercio, C. ;

Lonardo, A. ;

Marchesini, G. ;

Marra, F. ;

Persico, M. ;

Prati, D. ;

Svegliati-Baroni, G. .

DIGESTIVE AND LIVER DISEASE, 2010, 42 (04) :272-282

[40] Nonalcoholic Fatty Liver Disease Cirrhosis: A Review of Its Epidemiology, Risk Factors, Clinical Presentation, Diagnosis, Management, and Prognosis [J].

Li, Bei ;

Zhang, Chuan ;

Zhan, Yu-Tao .

CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2018, 2018

← 1 2 3 4 5 →