The "Tricky Business" of Identifying Mechanisms of Resistance to Anti-PD-1

被引：4
作者：
Wilmott, James S. [1 ]
Rizos, Helen [1 ,2 ]
Scolyer, Richard A. [1 ,3 ]
Long, Georgina V. [1 ,4 ]
机构：
[1] Univ Sydney, Melanoma Inst Australia, Sydney, NSW, Australia
[2] Macquarie Univ, Dept Biomed Sci, Fac Med & Hlth Sci, N Ryde, NSW, Australia
[3] Royal Prince Alfred Hosp, Tissue Pathol & Diagnost Oncol, Camperdown, NSW, Australia
[4] Royal North Shore & Mater Hosp, Sydney, NSW, Australia
来源：
CLINICAL CANCER RESEARCH | 2017年 / 23卷 / 12期
关键词：
MELANOMA; BLOCKADE; THERAPY;
D O I：
10.1158/1078-0432.CCR-17-0669
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Resistance to immune checkpoint inhibitors can vary between patients and among metastases. Understanding the genomic, transcriptomic, and microenvironmental factors that contribute to this variability will reveal the mechanisms that tumors utilize to evade the therapeutic effects of checkpoint inhibitor immunotherapies and will enable us to develop strategies to overcome them. (C) 2017 AACR. See related article by Ascierto et al., p. 3168
引用
收藏
页码：2921 / 2923
页数：3
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