Dynamic Nanoparticle Assemblies for Biomedical Applications

被引：191
作者：
Li, Fangyuan [1 ,2 ]
Lu, Jingxiong [1 ]
Kong, Xueqian [5 ]
Hyeon, Taeghwan [3 ,4 ]
Ling, Daishun [1 ,2 ]
机构：
[1] Zhejiang Univ, Coll Pharmaceut Sci, Zhejiang Prov Key Lab Anticanc Drug Res, Hangzhou 310058, Zhejiang, Peoples R China
[2] Zhejiang Univ, Coll Biomed Engn & Instrument Sci, Minist Educ, Key Lab Biomed Engn, Hangzhou 310027, Zhejiang, Peoples R China
[3] Inst for Basic Sci Korea, Ctr Nanoparticle Res, Seoul 08826, South Korea
[4] Seoul Natl Univ, Sch Chem & Biol Engn, Seoul 08826, South Korea
[5] Zhejiang Univ, Dept Chem, Hangzhou 310058, Zhejiang, Peoples R China
来源：
ADVANCED MATERIALS | 2017年 / 29卷 / 14期
基金：
中国国家自然科学基金;
关键词：
IRON-OXIDE NANOPARTICLES; MESOPOROUS SILICA NANOPARTICLES; LIGHT-TRIGGERED RELEASE; RESPONSIVE NANOPARTICLES; MAGNETIC NANOPARTICLES; GOLD NANOPARTICLES; DRUG-DELIVERY; COLLOIDAL NANOCRYSTALS; FUNCTIONAL MATERIALS; SMART POLYMERS;
D O I：
10.1002/adma.201605897
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Designed synthesis and assembly of nanoparticles assisted by their surface ligands can create " smart" materials with programmed responses to external stimuli for biomedical applications. These assemblies can be designed to respond either exogenously (for example, to magnetic field, temperature, ultrasound, light, or electric pulses) or endogenously (to pH, enzymatic activity, or redox gradients) and play an increasingly important role in a diverse range of biomedical applications, such as biosensors, drug delivery, molecular imaging, and novel theranostic systems. In this review, the recent advances and challenges in the development of stimuli-responsive nanoparticle assemblies are summarized; in particular, the application-driven design of surface ligands for stimuli-responsive nanoparticle assemblies that are capable of sensing small changes in the disease microenvironment, which induce the related changes in their physico-chemical properties, is described. Finally, possible future research directions and problems that have to be addressed are briefly discussed.
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页数：30
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