Cancer-related thrombotic microangiopathy secondary to Von Willebrand factor-cleaving protease deficiency

被引：27
作者：
Blot, E
Decaudin, D
Veyradier, A
Bardier, A
Zagame, OL
Pouillart, P
机构：
[1] Inst Curie, Dept Med Oncol, F-75231 Paris 05, France
[2] Inst Curie, Hematol Unit, F-75231 Paris, France
[3] Hop Bicetre, INSERM, U143, F-94276 Le Kremlin Bicetre, France
来源：
THROMBOSIS RESEARCH | 2002年 / 106卷 / 02期
关键词：
cancer; metastasis; thrombotic microangiopathy; Von Willebrand factor; protease;
D O I：
10.1016/S0049-3848(02)00095-6
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Cancer-related thrombotic microangiopathy (TM) is a serious complication with a short-term life-threatening prognosis. This complication shares certain similarities with thrombotic thrombocytopenic purpura. and hemolytic uremic syndrome, both characterized by circulating platelet aggregates containing ultralarge multimers of Von Willebrand factor (VWF). We report a case of cancer-related thrombotic microangiopathy secondary to disseminated metastatic cancer with undetectable serum Von Willebrand factor-cleaving protease activity and no evidence of serum inhibitory antibody. A concomitant decrease of Ca 19-9 level and hemolysis was observed during chemotherapy, in parallel with normalization of Von Willebrand factor-cleaving protease activity. The role of ultralarge multimers of Von Willebrand factor in platelet aggregation in the context of metastatic disease is discussed with respect to our findings in this case of cancer-related thrombotic microangiopathy. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：127 / 130
页数：4
相关论文
共 14 条
  • [1] MICRO-ANGIOPATHIC HEMOLYTIC-ANEMIA AND CANCER - REVIEW
    ANTMAN, KH
    SKARIN, AT
    MAYER, RJ
    HARGREAVES, HK
    CANELLOS, GP
    [J]. MEDICINE, 1979, 58 (05) : 377 - 384
  • [2] Thrombotic microangiopathy due to cancer is an oncological emergency: a case report
    Blot, E
    Marie, I
    Delastre, O
    Cailleux, N
    Pouillart, P
    Levesque, H
    Courtois, H
    [J]. REVUE DE MEDECINE INTERNE, 1999, 20 (05): : 448 - 449
  • [3] Microangiopathy in kidney and simultaneous pancreas/kidney recipients treated with tacrolimus: Evidence of endothelin and cytokine involvement
    Burke, GW
    Ciancio, G
    Cirocco, R
    Markou, M
    Olson, L
    Contreras, N
    Roth, D
    Esquenazi, V
    Tzakis, A
    Miller, J
    [J]. TRANSPLANTATION, 1999, 68 (09) : 1336 - 1342
  • [4] Von Willebrand factor-cleaving protease in thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome
    Furlan, M
    Robles, R
    Galbusera, M
    Remuzzi, G
    Kyrle, PA
    Brenner, B
    Krause, M
    Scharrer, I
    Aumann, V
    Mittler, U
    Solenthaler, M
    Lämmle, B
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1998, 339 (22) : 1578 - 1584
  • [5] von Willebrand factor: molecular size and functional activity
    Furlan, M
    [J]. ANNALS OF HEMATOLOGY, 1996, 72 (06) : 341 - 348
  • [6] Partial purification and characterization of a protease from human plasma cleaving von Willebrand factor to fragments produced by in vivo proteolysis
    Furlan, M
    Robles, R
    Lammle, B
    [J]. BLOOD, 1996, 87 (10) : 4223 - 4234
  • [7] UNUSUALLY LARGE PLASMA FACTOR-VIII - VONWILLEBRAND-FACTOR MULTIMERS IN CHRONIC RELAPSING THROMBOTIC THROMBOCYTOPENIC PURPURA
    MOAKE, JL
    RUDY, CK
    TROLL, JH
    WEINSTEIN, MJ
    COLANNINO, NM
    AZOCAR, J
    SEDER, RH
    HONG, SL
    DEYKIN, D
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1982, 307 (23) : 1432 - 1435
  • [8] Obert B, 1999, THROMB HAEMOSTASIS, V82, P1382
  • [9] Oleksowicz L, 1999, CANCER RES, V59, P2244
  • [10] Human breast carcinoma cells synthesize a protein immunorelated to platelet glycoprotein-Ib alpha with different functional properties
    Oleksowicz, L
    Dutcher, JP
    DeleonFernandez, M
    Paietta, E
    Etkind, P
    [J]. JOURNAL OF LABORATORY AND CLINICAL MEDICINE, 1997, 129 (03): : 337 - 346
12