Genetic And Epigenetic Regulation Of E-Cadherin Signaling In Human Hepatocellular Carcinoma

被引：35

作者：

Fan, Xiaoxiao ^{[1
]}

Jin, Shengxi ^{[1
,2
]}

Li, Yirun ^{[1
]}

Khadaroo, Parikshit Asutosh ^{[2
,3
]}

Dai, Yili ^{[1
,2
]}

He, Lifeng ^{[1
]}

Zhou, Daizhan ^{[1
]}

Lin, Hui ^{[1
]}

机构：

[1] Zhejiang Univ, Sch Med, Sir Run Run Shaw Hosp, Dept Gen Surg, 3 East Qingchun Rd, Hangzhou 310016, Zhejiang, Peoples R China

[2] Zhejiang Univ, Sch Med, Hangzhou, Zhejiang, Peoples R China

[3] Monash Univ, Sch Publ Hlth & Prevent Med, Melbourne, Vic, Australia

来源：

CANCER MANAGEMENT AND RESEARCH | 2019年 / 11卷

基金：

中国国家自然科学基金;

关键词：

E-cadherin; HCC; genetic alterations; epigenetic alterations; EPITHELIAL-MESENCHYMAL TRANSITION; HEPATITIS-B-VIRUS; REPRESSES E-CADHERIN; INVASION-SUPPRESSOR GENE; TUMOR-CELL PROLIFERATION; TGF-BETA PROMOTES; NONCODING RNA; DOWN-REGULATION; PROGNOSTIC BIOMARKER; HISTONE METHYLATION;

D O I：

10.2147/CMAR.S225606

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

E-cadherin is well known as a growth and invasion suppressor and belongs to the large cadherin family. Loss of E-cadherin is widely known as the hallmark of epithelial-to-mesenchymal transition (EMT) with the involvement of transcription factors such as Snail, Slug, Twist and Zeb1/2. Tumor cells undergoing EMT could migrate to distant sites and become metastases. Recently, numerous studies have revealed how the expression of E-cadherin is regulated by different kinds of genetic and epigenetic alteration, which are implicated in several crucial transcription factors and pathways. E-cadherin signaling plays an important role in hepatocellular carcinoma (HCC) initiation and progression considering the highly mutated frequency of CTNNB1 (27%). Combining the data from The Cancer Genome Atlas (TCGA) database and previous studies, we have summarized the roles of gene mutations, chromosome instability, DNA methylation, histone modifications and non-coding RNA in E-cadherin in HCC. In this review, we discuss the current understanding of the relationship between these modifications and HCC. Perspectives on E-cadherin-related research in HCC are provided.

引用

页码：8947 / 8963

页数：17

共 212 条

[71] Down-Regulated MicroRNA-152 Induces Aberrant DNA Methylation in Hepatitis B Virus-Related Hepatocellular Carcinoma by Targeting DNA Methyltransferase 1 [J].