Animal models of temporal lobe epilepsy following systemic chemoconvulsant administration

被引:175
作者
Levesque, Maxime [1 ,2 ]
Avoli, Massimo [1 ,2 ,3 ,4 ]
Bernard, Christophe [5 ]
机构
[1] McGill Univ, Montreal Neurol Inst, 3801 Univ St, Montreal, PQ H3A 2B4, Canada
[2] McGill Univ, Dept Neurol & Neurosurg, Montreal, PQ H3A 2B4, Canada
[3] McGill Univ, Dept Physiol, Montreal, PQ H3A 2B4, Canada
[4] Univ Roma La Sapienza, Dept Expt Med, Fac Med & Odontoiatry, I-00185 Rome, Italy
[5] Aix Marseille Univ, INSERM, INS UMR S 1106, F-13005 Marseille, France
基金
加拿大健康研究院;
关键词
Animal models; Kainic acid; Pilocarpine; Temporal lobe epilepsy; INDUCED STATUS EPILEPTICUS; SPONTANEOUS RECURRENT SEIZURES; HIGH-FREQUENCY OSCILLATIONS; KAINATE-INDUCED EPILEPSY; SPONTANEOUS MOTOR SEIZURES; KAINIC ACID INJECTION; PILOCARPINE MODEL; BEHAVIORAL ALTERATIONS; NEURONAL DAMAGE; FAST RIPPLES;
D O I
10.1016/j.jneumeth.2015.03.009
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
In order to understand the pathophysiology of temporal lobe epilepsy (TLE), and thus to develop new pharmacological treatments, in vivo animal models that present features similar to those seen in TLE patients have been developed during the last four decades. Some of these models are based on the systemic administration of chemoconvulsants to induce an initial precipitating injury (status epilepticus) that is followed by the appearance of recurrent seizures originating from limbic structures. In this paper we will review two chemically-induced TLE models, namely the kainic acid and pilocarpine models, which have been widely employed in basic epilepsy research. Specifically, we will take into consideration their behavioral, electroencephalographic and neuropathologic features. We will also evaluate the response of these models to anti-epileptic drugs and the impact they might have in developing new treatments for TLE. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码:45 / 52
页数:8
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