Hydrodefluorination Reactions Catalyzed by Transition-Metal Complexes

Activation of the C-F bond by transition-metal catalysts not only advances fundamental understanding of the formation and reactivity of organometallic fluoride complexes but also provides a potential approach to partially fluorinated organic compounds from readily available perfluorinated bulk chemicals. Hydrodefluorination (HDF) is regarded as a simple but important reaction among various C-F functionalizations, which features a mechanistic diversity as model reactions for C-F bond activations. Following Lentz and Braun's review (Angew Chem Int Ed 52, 3328-3348, 2013), we review transition-metal-mediated HDF reactions according to periodic table from group 3-12 metals.