Surface Characterization, Biocompatibility and Antifungal Efficacy of a Denture-Lining Material Containing Cnidium officinale Extracts

被引：8
作者：
Lee, Myung-Jin [1 ]
Shim, Youn-Soo [2 ]
An, So-Youn [3 ,4 ]
Kang, Min-Kyung [5 ]
机构：
[1] Baekseok Univ, Div Hlth Sci, Dept Dent Hyg, Cheonan 31065, Chungcheongnam, South Korea
[2] Sunmoon Univ, Dept Dent Hyg, Asan 31460, Chungcheongnam, South Korea
[3] Wonkwang Univ, Coll Dent, Dept Pediat Dent, Iksan Si 5453, Jeollabuk Do, South Korea
[4] Wonkwang Univ, Coll Dent, Wonkwang Bone Regenerat Res Inst, Iksan Si 5453, Jeollabuk Do, South Korea
[5] Hanseo Univ, Dept Dent Hyg, Seosan 31963, Chungcheongnam, South Korea
来源：
MOLECULES | 2021年 / 26卷 / 05期
基金：
新加坡国家研究基金会;
关键词：
antifungal efficacy; biocompatibility; Candida albicans; Cnidium officinale; denture-relining material; surface characterization;
D O I：
10.3390/molecules26051440
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Herein, we investigated the surface characterization and biocompatibility of a denture-lining material containing Cnidium officinale extracts and its antifungal efficacy against Candida albicans. To achieve this, a denture-lining material containing various concentrations of C. officinale extract and a control group without C. officinale extract were prepared. The surface characterization and biocompatibility of the samples were investigated. In addition, the antifungal efficacy of the samples on C. albicans was investigated using spectrophotometric growth and a LIVE/DEAD assay. The results revealed that there was no significant difference between the biocompatibility of the experimental and control groups (p > 0.05). However, there was a significant difference between the antifungal efficiency of the denture material on C. albicans and that of the control group (p < 0.05), which was confirmed by the LIVE/DEAD assay. These results indicate the promising potential of the C. officinale extract-containing denture-lining material as an antifungal dental material.
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页数：9
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