T follicular helper cells, interleukin-21 and systemic lupus erythematosus

被引：49

作者：

Gensous, Noemie ^{[1
]}

Schmitt, Nathalie ^{[1
]}

Richez, Christophe ^{[1
]}

Ueno, Hideki ^{[2
]}

Blanco, Patrick ^{[1
]}

机构：

[1] Univ Bordeaux, UMR CNRS 5164, Bordeaux, France

[2] Baylor Res Inst, Baylor Inst Immunol Res, Dallas, TX USA

来源：

RHEUMATOLOGY | 2017年 / 56卷 / 04期

关键词：

autoimmunity; lupus; pathogenesis; T lymphocyte; B lymphocyte; antigen-presenting cell; co-stimulatory molecule; TNFSF4; IL-21; immunoglobulins; GERMINAL CENTER FORMATION; CXC CHEMOKINE RECEPTOR-5; DOUBLE-EDGED-SWORD; BXSB-YAA MICE; B-CELL; INDUCIBLE COSTIMULATOR; HUMORAL IMMUNITY; IL-21; RECEPTOR; IMMUNOGLOBULIN PRODUCTION; AUTOCRINE REGULATION;

D O I：

10.1093/rheumatology/kew297

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

SLE is a chronic systemic autoimmune disease characterized by a breakdown of tolerance to nuclear antigens and generation of high-affinity pathogenic autoantibodies. These autoantibodies form, with autoantigens, immune complexes that are involved in organ and tissue damages. Understanding how the production of these pathogenic autoantibodies arises is of prime importance. T follicular helper cells (Tfh) and IL-21 have emerged as central players in this process. This article reviews the pathogenic role of Tfh cells and IL-21 in SLE.

引用

收藏

页码：516 / 523

页数：8

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