Widespread Mechanical Pain Hypersensitivity as Sign of Central Sensitization in Unilateral Epicondylalgia A Blinded, Controlled Study

被引:140
作者
Fernandez-Carnero, Josue [1 ,2 ]
Fernandez-de-las-Penas, Cesar [2 ]
de la Llave-Rincon, Ana Isabel [2 ]
Ge, Hong-You [3 ]
Arendt-Nielsen, Lars [3 ]
机构
[1] Univ Rey Juan Carlos, Fac Ciencias Salud, Dept Phys Therapy Occupat Therapy Rehabil & Phys, Madrid 28922, Spain
[2] Univ Rey Juan Carlos, Esthesiol Lab, Madrid 28922, Spain
[3] Univ Aalborg, Dept Hlth Sci & Technol, Ctr Sensory Motor Interact, Aalborg, Denmark
关键词
lateral epicondylalgia; pain; central sensitization; pressure pain thresholds; MYOFASCIAL TRIGGER POINTS; WHIPLASH-ASSOCIATED DISORDER; NOXIOUS INHIBITORY CONTROLS; LATERAL EPICONDYLALGIA; TENNIS ELBOW; TEMPORAL SUMMATION; MUSCLE PAIN; SENSORY HYPERSENSITIVITY; GENDER-DIFFERENCES; FOREARM MUSCLES;
D O I
10.1097/AJP.0b013e3181a68a040
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Objective: The aim of this study was to investigate whether generalized deep tissue hyperalgesia exists in patients with chronic unilateral lateral epicondylalgia (LE). Methods: A total of 26 LE patients (10 males and 16 females, aged 25 to 63 y) and 20 healthy comparable matched controls (aged 26 to 61 y) were recruited and pressure pain threshold (PPT) was assessed bilaterally over the median, ulnar, and radial nerve trunks, the lateral epicondyle, C5-C6 zygapophyseal joint, and the tibialis anterior muscle in a blind design. Results: PPT was significantly decreased bilaterally over the median, ulnar, and radial nerve trunks, the lateral epicondyle, the C5-C6 zygapophyseal joint, and tibialis,interior muscle in patients with LE than healthy controls (all P < 0,001). PPTs over those measured points was negatively related to current elbow pain intensity (all P < 0.05). A more significant decrease in PPTs were present in females (all P < 0.05). Conclusions: This revealed a widespread mechanical hypersensitivity in patients with LE, which suggest that central sensitization mechanisms are involved in patients with unilateral LE. The generalized decrease in PPT levels was associated with elbow pain intensity, supporting a role of peripheral sensitization mechanisms in the initiation or maintenance of central sensitization mechanisms. In addition, females may be more prone to the development of generalized mechanical hypersensitivity.
引用
收藏
页码:555 / 561
页数:7
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