Cyclin-dependent kinase 5 (Cdk5) associated with Lewy bodies in diffuse Lewy body disease

被引：28

作者：

Takahashi, M ^{[1
]}

Iseki, E ^{[1
]}

Kosaka, K ^{[1
]}

机构：

[1] Yokohama City Univ, Sch Med, Dept Psychiat, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan

来源：

BRAIN RESEARCH | 2000年 / 862卷 / 1-2期

关键词：

Lewy body; dementia with Lewy bodies; diffuse Lewy body disease; cyclin-dependent kinase 5; immunohistochemistry;

D O I：

10.1016/S0006-8993(00)02086-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigated the cyclin-dependent kinase (Cdk) 5 distribution pattern in diffuse Lewy body disease brains using immunohistochemistry. Cdk5 immunoreactivity was detected in both brainstem-type Lewy bodies (LBs) and cortical LBs. The number of Cdk5-positive LBs was less than that of ubiquitin- or alpha-synuclein-positive LBs, and more than that of phosphorylated neurofilament-positive LBs. Immunoelectron microscopy revealed Cdk5-immunolabeled granulo-filamentous components in LBs and LB-related neurites. These data suggest that Cdk5 may be associated with LB formation. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：253 / 256

页数：4

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