Antimicrobial and immunoregulatory effector mechanisms in human endothelial cells Indoleamine 2,3-dioxygenase versus inducible nitric oxide synthase

被引：31

作者：

Daeubener, Walter

Schmidt, Silvia K.

Heseler, Kathrin

Spekker, Katrin H.

MacKenzie, Colin R.

机构：

[1] Univ Dusseldorf, Inst Med Microbiol, D-40225 Dusseldorf, Germany

[2] Univ Dusseldorf, Hosp Hyg, D-40225 Dusseldorf, Germany

来源：

THROMBOSIS AND HAEMOSTASIS | 2009年 / 102卷 / 06期

关键词：

Endothelial cells; inducible nitric oxide synthase; indoleamine 2,3-dioxygenase; interferon-gamma; effector mechanisms; NECROSIS-FACTOR-ALPHA; INTERFERON-GAMMA; HUMAN CYTOMEGALOVIRUS; TOXOPLASMA-GONDII; TRYPTOPHAN CATABOLISM; STAPHYLOCOCCUS-AUREUS; IFN-GAMMA; EXPRESSION; INHIBITION; ACTIVATION;

D O I：

10.1160/TH09-04-0250

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In infectious diseases, interferon-gamma (IFN-gamma) is generally accepted as one of the most important inducers of antimicrobial and immunoregulatory effects, and both seemingly contradictory effects, can be mediated by the same effector molecules. In detail,several IFN-gamma induced enzymes such as the inducible nitric oxide synthase (iNOS) as well as the indoleamine 2,3-dioxygenase (IDO) also exert this double function. In this review we focus on antimicrobial and immunoregulatory properties of both enzymes expressed by human endothelial cells, which are prominent players in infectious diseases, tumour immunology and transplant medicine.

引用

收藏

页码：1110 / 1116

页数：7

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