Antimicrobial and immunoregulatory effector mechanisms in human endothelial cells Indoleamine 2,3-dioxygenase versus inducible nitric oxide synthase

被引：33
作者：
Daeubener, Walter
Schmidt, Silvia K.
Heseler, Kathrin
Spekker, Katrin H.
MacKenzie, Colin R.
机构：
[1] Univ Dusseldorf, Inst Med Microbiol, D-40225 Dusseldorf, Germany
[2] Univ Dusseldorf, Hosp Hyg, D-40225 Dusseldorf, Germany
来源：
THROMBOSIS AND HAEMOSTASIS | 2009年 / 102卷 / 06期
关键词：
Endothelial cells; inducible nitric oxide synthase; indoleamine 2,3-dioxygenase; interferon-gamma; effector mechanisms; NECROSIS-FACTOR-ALPHA; INTERFERON-GAMMA; HUMAN CYTOMEGALOVIRUS; TOXOPLASMA-GONDII; TRYPTOPHAN CATABOLISM; STAPHYLOCOCCUS-AUREUS; IFN-GAMMA; EXPRESSION; INHIBITION; ACTIVATION;
D O I：
10.1160/TH09-04-0250
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In infectious diseases, interferon-gamma (IFN-gamma) is generally accepted as one of the most important inducers of antimicrobial and immunoregulatory effects, and both seemingly contradictory effects, can be mediated by the same effector molecules. In detail,several IFN-gamma induced enzymes such as the inducible nitric oxide synthase (iNOS) as well as the indoleamine 2,3-dioxygenase (IDO) also exert this double function. In this review we focus on antimicrobial and immunoregulatory properties of both enzymes expressed by human endothelial cells, which are prominent players in infectious diseases, tumour immunology and transplant medicine.
引用
收藏
页码：1110 / 1116
页数：7
相关论文
共 64 条
[1]   Role of human brain microvascular endothelial cells during central nervous system infection -: Significance of indoleamine 2,3-dioxygenase in antimicrobial defence and immunoregulation [J].
Adam, R ;
Rüssing, D ;
Adams, O ;
Ailyati, A ;
Kim, KS ;
Schroten, H ;
Däubener, W .
THROMBOSIS AND HAEMOSTASIS, 2005, 94 (02) :341-346
[2]   Porcine choroid plexus epithelial cells induce Streptococcus suis bacteriostasis in vitro [J].
Adam, RA ;
Tenenbaum, T ;
Valentin-Weigand, P ;
Laryea, M ;
Schwahn, B ;
Angelow, S ;
Galla, HJ ;
Däubener, W ;
Schroten, H .
INFECTION AND IMMUNITY, 2004, 72 (05) :3084-3087
[3]   Role of indoleamine-2,3-dioxygenase in alpha/beta and gamma interferon-mediated antiviral effects against herpes simplex virus infections [J].
Adams, O ;
Besken, K ;
Oberdörfer, C ;
MacKenzie, CR ;
Takikawa, O ;
Däubener, W .
JOURNAL OF VIROLOGY, 2004, 78 (05) :2632-2636
[4]   Inhibition of human herpes simplex virus type 2 by interferon γ and tumor necrosis factor α is mediated by indoleamine 2,3-dioxygenase [J].
Adams, O ;
Besken, K ;
Oberdörfer, C ;
MacKenzie, CR ;
Rüssing, D ;
Däubener, W .
MICROBES AND INFECTION, 2004, 6 (09) :806-812
[5]  
Assis MC, 2006, INT J MOL MED, V18, P355
[6]   Gamma interferon confers resistance to infection with Staphylococcus aureus in human vascular endothelial cells by cooperative proinflammatory and enhanced intrinsic antibacterial activities [J].
Beekhuizen, Henry ;
De Gevel, Joke S. Van .
INFECTION AND IMMUNITY, 2007, 75 (12) :5615-5626
[7]   Function of indoleamine 2,3-dioxygenase in corneal allograft rejection and prolongation of allograft survival by over-expression [J].
Beutelspacher, SC ;
Pillai, R ;
Watson, MP ;
Tan, PH ;
Tsang, J ;
McClure, MO ;
George, AJT ;
Larkin, DFP .
EUROPEAN JOURNAL OF IMMUNOLOGY, 2006, 36 (03) :690-700
[8]   Expression of indoleamine 2,3-dioxygenase (IDO) by endothelial cells: Implications for the control of alloresponses [J].
Beutelspacher, SC ;
Tan, PH ;
McClure, MO ;
Larkin, DFP ;
Lechler, RI ;
George, AJT .
AMERICAN JOURNAL OF TRANSPLANTATION, 2006, 6 (06) :1320-1330
[9]  
Bodaghi B, 1999, J IMMUNOL, V162, P957
[10]   Reactive oxygen and reactive nitrogen intermediates in innate and specific immunity [J].
Bogdan, C ;
Röllinghoff, M ;
Diefenbach, A .
CURRENT OPINION IN IMMUNOLOGY, 2000, 12 (01) :64-76
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