Mycobacterium tuberculosis Beijing Genotype Is an Independent Risk Factor for Tuberculosis Treatment Failure in Indonesia

被引：65

作者：

Parwati, Ida ^{[3
,6
]}

Alisjahbana, Bachti ^{[4
,6
]}

Apriani, Lika ^{[6
]}

Soetikno, Rista D. ^{[5
]}

Ottenhoff, Tom H. ^{[7
]}

van der Zanden, Adri G. M. ^{[8
]}

van der Meer, Jos ^{[1
,2
]}

van Soolingen, Dick ^{[9
]}

van Crevel, Reinout ^{[1
,2
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Dept Internal Med, NL-6500 HB Nijmegen, Netherlands

[2] Radboud Univ Nijmegen, Med Ctr, Nijmegen Inst Infect Inflammat & Immun, NL-6500 HB Nijmegen, Netherlands

[3] Padjadjaran State Univ, Fac Med, Hasan Sadikin Hosp, Dept Clin Pathol, Bandung, Indonesia

[4] Padjadjaran State Univ, Fac Med, Hasan Sadikin Hosp, Dept Internal Med, Bandung, Indonesia

[5] Padjadjaran State Univ, Fac Med, Hasan Sadikin Hosp, Dept Radiol, Bandung, Indonesia

[6] Padjadjaran State Univ, Fac Med, Hasan Sadikin Hosp, Hlth Res Unit, Bandung, Indonesia

[7] Leiden Univ, Med Ctr, Dept Infect Dis, Leiden, Netherlands

[8] Lab Med Microbiol & Publ Hlth, Enschede, Netherlands

[9] Natl Inst Publ Hlth & Environm, Natl TB Reference Lab, NL-3720 BA Bilthoven, Netherlands

来源：

JOURNAL OF INFECTIOUS DISEASES | 2010年 / 201卷 / 04期

关键词：

RESISTANCE; INFECTION; VIRULENCE;

D O I：

10.1086/650311

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Animal studies have shown that the globally emerging Beijing genotype strains of Mycobacterium tuberculosis are more virulent than other strains. We examined whether Beijing strains increase treatment failure in a prospective cohort study in Indonesia. Among 818 tuberculosis cases, positive sputum culture results after 6 months of treatment were more common among patients infected with Beijing strains (33.4%) than among those infected with non-Beijing strains (relative risk, 1.94 [95% confidence interval, 1.26-3.00]), even after adjustment for differences in drug resistance. These data suggest that M. tuberculosis Beijing genotype strains have a higher capacity to withstand tuberculosis treatment, even in the absence of drug resistance.

引用

页码：553 / 557

页数：5

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