Actin, microtubules and focal adhesion dynamics during cell migration

被引：175
作者：
Wehrle-Haller, B [1 ]
Imhof, BA [1 ]
机构：
[1] Ctr Med Univ Geneva, Dept Pathol, CH-1211 Geneva 4, Switzerland
来源：
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2003年 / 35卷 / 01期
关键词：
green fluorescent protein; cytoskeleton; actin; tubulin; focal adhesion; migration;
D O I：
10.1016/S1357-2725(02)00071-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cell migration is a complex cellular behavior that results from the coordinated changes in the actin cytoskeleton and the controlled formation and dispersal of cell-substrate adhesion sites. While the actin cytoskeleton provides the driving force at the cell front, the microtubule network assumes a regulatory function in coordinating rear retraction. The polarity within migrating cells is further highlighted by the stationary behavior of focal adhesions in the front and their sliding in trailing ends. We discuss here the cross-talk of the actin cytoskeleton with the microtubule network and the potential mechanisms that control the differential behavior of focal adhesions sites during cell migration. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：39 / 50
页数：12
相关论文
共 99 条
[1]   Contact dynamics during keratocyte motility [J].
Anderson, KI ;
Cross, R .
CURRENT BIOLOGY, 2000, 10 (05) :253-260
[2]   Actin-dependent lamellipodia formation and microtubule-dependent tail retraction control-directed cell migration [J].
Ballestrem, C ;
Wehrle-Haller, B ;
Hinz, B ;
Imhof, BA .
MOLECULAR BIOLOGY OF THE CELL, 2000, 11 (09) :2999-3012
[3]   Marching at the front and dragging behind:: differential α-Vβ3-integrin turnover regulates focal adhesion behavior [J].
Ballestrem, C ;
Hinz, B ;
Imhof, BA ;
Wehrle-Haller, B .
JOURNAL OF CELL BIOLOGY, 2001, 155 (07) :1319-1332
[4]  
Ballestrem C, 1998, J CELL SCI, V111, P1649
[5]   Involvement of microtubules in the control of adhesion-dependent signal transduction [J].
Bershadsky, A ;
Chausovsky, A ;
Becker, E ;
Lyubimova, A ;
Geiger, B .
CURRENT BIOLOGY, 1996, 6 (10) :1279-1289
[6]   PSEUDOPODIAL ACTIVITY AT THE ACTIVE EDGE OF MIGRATING FIBROBLAST IS DECREASED AFTER DRUG-INDUCED MICROTUBULE DEPOLYMERIZATION [J].
BERSHADSKY, AD ;
VAISBERG, EA ;
VASILIEV, JM .
CELL MOTILITY AND THE CYTOSKELETON, 1991, 19 (03) :152-158
[7]  
Best A, 1996, J BIOL CHEM, V271, P3756
[8]   Actin machinery: pushing the envelope [J].
Borisy, GG ;
Svitkina, TM .
CURRENT OPINION IN CELL BIOLOGY, 2000, 12 (01) :104-112
[9]   Moving membrane up to the front of migrating cells [J].
Bretscher, MS .
CELL, 1996, 85 (04) :465-467
[10]   EGF induces recycling membrane to form ruffles [J].
Bretscher, MS ;
Aguado-Velasco, C .
CURRENT BIOLOGY, 1998, 8 (12) :721-724
12345678910