Smoking history influences the prognostic value of peripheral naive CD4+T cells in advanced non-small cell lung cancer

被引：8

作者：

Liu, Chao ^{[1
,2
,3
]}

Xu, Bin ^{[1
]}

Li, Qian ^{[1
]}

Li, Aijie ^{[4
]}

Li, Lan ^{[1
]}

Yue, Jinbo ^{[2
]}

Hu, Qinyong ^{[1
]}

Yu, Jinming ^{[1
,2
]}

机构：

[1] Wuhan Univ, Renmin Hosp, Dept Oncol, Wuhan 430060, Hubei, Peoples R China

[2] Shandong First Med Univ & Shandong Acad Med Sci, Shandong Canc Hosp & Inst, Dept Radiat Oncol, Jinan 250117, Shandong, Peoples R China

[3] Acad Mil Med Sci, Affiliated Hosp, Dept Radiat Oncol, Beijing 100071, Peoples R China

[4] Weifang Med Univ, Weifang 261053, Shandong, Peoples R China

来源：

CANCER CELL INTERNATIONAL | 2019年 / 19卷 / 1期

基金：

中国国家自然科学基金;

关键词：

Memory T cells; Naive T cells; Non-small cell lung cancer; Cigarette; TUMOR-INFILTRATING LYMPHOCYTES; CD4(+) T-CELLS; OPEN-LABEL; PEMBROLIZUMAB; DOCETAXEL; NIVOLUMAB; BIOPSY; PNEUMOTHORAX; ATEZOLIZUMAB; MULTICENTER;

D O I：

10.1186/s12935-019-0899-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BackgroundConsidering the effect of smoking on tumor immunity, we attempted to investigate the impact of smoking history on the prognostic value of circulating naive and memory CD4+ and CD8+ T cells in advanced non-small cell lung cancer (NSCLC) treated with chemo(radio)therapy.MethodsOf 196 histologically confirmed advanced NSCLC, 98 eligible ones were enrolled. Naive and memory CD4+ and CD8+ T cells from peripheral blood were measured by flow cytometry. Kaplan-Meier curves helped estimate patients' survival. The uni- and multivariate Cox proportional hazards regression model was employed in the assessment of the prognostic value of factors.ResultsMultivariate survival analyses showed that peripheral naive CD4+ T cells independently predicted favorable overall survival (OS) in ever smokers with advanced NSCLC (P=0.007), but unfavorable OS in never smokers with the same ailment (P=0.012). Ever smokers presented a different distribution of naive and memory T cells: low expression levels of naive CD4+ T (P=0.005), naive CD8+ T (P=0.031), CD4+ naive/memory ratio (P=0.020), and CD8+ naive/memory ratio (P=0.019), and high distributions of memory CD4+T (P=0.004), memory CD8+T (P=0.034), and naive CD8/CD4 ratio (P=0.020), when compared to never smokers.ConclusionsWe revealed the impact of cigarette-smoking on peripheral naive CD4+ T cells' prognostic value in advanced NSCLC patients. These results could help in refining personalized treatment for advanced NSCLC patients.

引用

页数：9

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